Falling asleep after a big meal: Neuronal regulation of satiety.
Falling asleep after a big meal: Neuronal regulation of satiety.
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DOI：
10.4161/worm.27938
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
You YJ
中科院分区：
文献类型：
--
作者：
Gallagher T;You YJ
C.由于线虫在食欲控制和摄食行为调控的分子机制上具有很强的保守性，因而成为研究食欲控制和能量代谢遗传学的理想模型。蠕虫的饱足行为与哺乳动物的饱足行为特别相似，因为蠕虫在饱餐一顿后变得安静，模仿哺乳动物的餐后睡眠。在这里，我们回顾了我们最近的发现，关于神经元调节的行为和发现的含义，如行为状态的周期性。基于这一发现，我们提出了一个相当投机但有趣的观点，即新陈代谢如何与餐后睡眠联系在一起。
C. elegans has become an ideal model to study genetics of appetite control and energy metabolism because of its robust conservation in molecular mechanisms underlying appetite control and in regulation of the relevant feeding behavior. Satiety behavior in worms in particular shows striking similarities to that in mammals, as a worm becomes quiescent after a big meal, mimicking post-prandial sleep in mammals. Here we review our recent finding regarding the neuronal regulation of the behavior and the implication of the finding such as cyclicity of behavioral states. Based on the finding, we propose a rather speculative but intriguing view of how metabolism could link to post-prandial sleep.