Chemically induced cell fate reprogramming and the acquisition of plasticity in somatic cells.
Chemically induced cell fate reprogramming and the acquisition of plasticity in somatic cells.
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DOI：
10.1016/j.cbpa.2019.04.025
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发表时间：
2019-08
影响因子：
7.8
通讯作者：
Yang Zhao
中科院分区：
文献类型：
--
作者：
Yang Zhao
体细胞命运的本质一直被认为是相对不可改变的。只有在极少数情况下，在高度特定的环境提示下，分化的哺乳动物体细胞才会转化为其他细胞类型。然而，细胞命运重编程可以在没有任何遗传改变的情况下通过化学混合物来完成，这一事实表明，体细胞命运的决定比以前认为的更具可塑性。使用化学混合物直接改变细胞的命运，揭示了再生医学的一个重要但尚未被探索的方法：使用化学物质来恢复受伤、衰老或患病组织的功能。在这里，我们回顾和讨论了化学物质调节细胞命运重编程的最新进展、启示和面临的挑战，并探讨了化学生物学如何影响细胞命运重编程和再生医学的未来。
The nature of somatic cell fate has always been considered relatively unchangeable. Only in rare cases, in response to highly specific environmental cues, do differentiated mammalian somatic cells transform into other cell types. However, the fact that cell fate reprogramming can be accomplished by utilizing chemical cocktails, in the absence of any genetic alterations, suggests that the fate determination of somatic cells is much more malleable than previously believed. The use of chemical cocktails to directly alter cell fate sheds light on an important, yet less explored approach to regenerative medicine: the use of chemicals to restore functions to injured, aging or diseased tissues. Here, we review and discuss the recent developments, inspirations, and challenges encountered when modulating cell fate reprogramming with chemicals, and investigate how chemical biology impacts the future of cell fate reprogramming and regenerative medicine.