Maternal, birth, and early-life influences on adult body size in women
Maternal, birth, and early-life influences on adult body size in women
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DOI：
10.1093/aje/kwm094
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发表时间：
2007-07-01
影响因子：
5
通讯作者：
Esserman, Denise
中科院分区：
文献类型：
--
作者：
Terry, Mary Beth;Wei, Ying;Esserman, Denise
作者对1959-1965年间出生的261名女性（38%白人，40%非裔美国人，22%拉丁裔）进行了随访研究，以调查在考虑了儿童生长后，母亲和婴儿因素是否与成年后的体型独立相关。将标准统计方法（线性回归和逻辑回归）与分位数回归方法进行比较，以评估母体因素(体重指数(BMI；体重（kg)/身高（m)(2)）、母体体重增加）、出生指标（出生体重、胎盘体重）、婴幼儿早期生长指标（出生-4个月、4个月-1岁和1-7岁）对预测成人体重的独立影响。虽然这些因素中的大多数都是20岁时BMI的重要预测因素，但影响的大小和相对重要性在不同的模型中有所不同。例如，母亲体重增加与20岁时体重超重（BMI >= 25）有关（每10磅（4.5公斤）变化，优势比= 1.65,95%可信区间：1.11,2.44），并与20岁时BMI的上分位数（>= 75百分位数）有关。相比之下，母亲的BMI和出生体重对于较低的分位数来说相对更重要，尤其是在40岁时。无论采用何种统计模型，只有从1岁到7岁的快速增长是20岁和40岁成人BMI的重要预测因子。然而，即使考虑到儿童时期的快速成长，母亲和婴儿因素对成人体重指数的持续影响表明，更有必要调查这些早期生活的影响，以及它们对身材矮小和身材高大的女性的影响是否不同。
The authors conducted a follow-up study of 261 women born during 1959-1965 (38% White, 40% African-American, and 22% Latina) to investigate whether maternal and infant factors are independently associated with adult body size after accounting for childhood growth. Standard statistical methods (linear regression and logistic regression) were compared with quantile regression methods to assess the independent effect maternal factors (body mass index (BMI; weight (kg)/height (m)(2)), maternal weight gain), birth measures (birth weight, placental weight), and early infancy and childhood growth measures (birth-4 months, 4 months-1 year, and 1-7 years) have on predicting adult body size. While most of these factors were important predictors of BMI at age 20 years, the size and relative importance of the effect differed across models. For example, maternal weight gain was associated with being overweight (BMI >= 25) at age 20 years (per 10-pound (4.5-kg) change, odds ratio = 1.65, 95% confidence interval: 1.11, 2.44) and was associated with the upper quantiles ( >= 75th percentile) of BMI at age 20 years. In contrast, maternal BMI and birth weight were relatively more important for lower quantiles, particularly at age 40 years. Only rapid growth from ages 1 to 7 years was an important predictor of adult BMI at both age 20 and age 40, irrespective of statistical model. However, the persistence of effects of maternal and infant factors on adult BMI, even after rapid childhood growth is accounted for, suggests a greater need to investigate these early-life influences and whether their impact differs for smaller and larger women.