Plasma levels of persistent organohalogens and hormone levels in adult male humans
Plasma levels of persistent organohalogens and hormone levels in adult male humans
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DOI：
10.1080/00039890109604065
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发表时间：
2001-03-01
期刊：
影响因子：
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通讯作者：
Erfurth, EM
中科院分区：
文献类型：
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作者：
Hagmar, L;Björk, J;Erfurth, EM
在这项研究中，作者评估了波罗的海富含脂肪的鱼类对持久性有机卤素（OHS）的高膳食暴露与成年男性激素水平之间的可能关系。从110名食用不同数量鱼类（即每月0-32餐）的男性中抽取血样，以分析血浆中18种多氯联苯（PCB）同族物、5种羟基多氯联苯、1,1,1-三氯-2,2-二（4-氯苯）-乙烷（p,p'-DDE）、1,1-二氯-2,2-二（4-氯苯）-乙烯（p,p'-DDE）、六氯苯和2,2',4,4'-四溴联苯醚的水平。分析血浆促卵泡激素、促黄体生成素、催乳素、血浆促甲状腺素、游离T3及总T3、游离T4及总T4、游离睾酮水平。作者调整了年龄，唯一的显著关联是2,2',4,4'-四溴联苯醚与血浆促甲状腺素之间的负相关
In this study the authors assessed the possible relationship between high dietary exposure to persistent organohalogens (OHS) through fatty fish from the Baltic Sea and hormone levels in adult men. Blood samples were drawn from 110 men who consumed varying amounts of fish (i.e., 0-32 meals per month) for analysis of plasma levels of 18 polychlorinated biphenyl (PCB) congeners, 5 hydroxy-PCBs, 1,1,1-trichloto-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE), hexachlorobenzene, and 2,2',4,4'-tetrabromodiphenyl ether. In addition, plasma levels of follicle-stimulating hormone, luteinizing hormone, prolactin, plasma thyrotropin, free and total T3, free and total T4, and free testosterone were analyzed. The authors adjusted for age, and the only significant associations that remained were negative correlations between 2,2',4,4'-tetrabromodiphenyl ether and plasma thyrotropin (p