Risk of upper aerodigestive tract cancers in a case-cohort study of autoworkers exposed to metalworking fluids.
Risk of upper aerodigestive tract cancers in a case-cohort study of autoworkers exposed to metalworking fluids.
复制标题
接触金属加工液的汽车工人的病例队列研究中上呼吸消化道癌症的风险。
DOI：
10.1136/oem.2003.010157
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发表时间：
2004
影响因子：
4.9
通讯作者：
Wegman,DH
中科院分区：
文献类型：
--
作者：
Zeka,A;Eisen,EA;Kriebel,D;Gore,R;Wegman,DH
目的：重新检查呼吸消化道癌症的风险在一个队列的汽车工人暴露于金属加工液（MWF），使用改进的情况下定义和最近诊断的cases.Methods：汽车工人队列包括31 100小时工活着1985年1月1日谁在密歇根州的三个汽车厂工作。进行了病例队列设计，包括喉癌、食道癌和胃癌的偶发病例，以及队列的10%样本。采用考克斯比例风险模型估计MWF暴露效应。惩罚样条的平滑方法被用来探索的基本dissure-response curves.Results的形状：最重要的发现是喉癌的发病率和累积直MWF暴露之间的关联。食管癌的结果不太一致。对于胃癌没有证据的超额risk.Conclusion：喉癌和直MWF暴露之间的这种关联是一致的，在这个队列中与以前的发现，提供了进一步的支持的因果关系。
Aims:To re-examine aerodigestive cancer risk in a cohort of autoworkers exposed to metal working fluids (MWF), using improved case definition and more recently diagnosed cases.Methods:The autoworker cohort included 31 100 hourly workers alive on 1 January 1985 who worked at three automobile plants in Michigan. A case-cohort design was carried out that included incident cases of cancers of the larynx, oesophagus, and stomach, and a 10% sample of the cohort. A Cox proportional hazards model was used to estimate MWF exposure effects. The smoothing method of penalised splines was used to explore the shape of the underlying exposure-response curves.Results:The most important finding was the association between larynx cancer incidence and cumulative straight MWF exposure. The results for oesophageal cancer were less consistent. For stomach cancer there was no evidence of excess risk.Conclusion:This association between larynx cancer and straight MWF exposures was consistent with a previous finding in this cohort, providing further support for a causal relation.