The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.
The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.
复制标题
DOI：
10.3389/fmed.2020.589553
复制
发表时间：
2020
影响因子：
3.9
通讯作者：
Weldon S
中科院分区：
文献类型：
--
作者：
Brown R;McKelvey MC;Ryan S;Creane S;Linden D;Kidney JC;McAuley DF;Taggart CC;Weldon S
急性呼吸窘迫综合征（ARDS）与老年人群（≥65岁）的发病率和死亡率增加相关。此外，年龄被广泛报道为发展ARDS的危险因素。然而，老年人群发生ARDS的风险增加和严重程度增加背后的潜在病理生理机制尚未完全了解。在ARDS患者中观察到的显著异质性加剧了这一问题。随着全球人口老龄化，更好地了解这些机制可以促进治疗的发展，以改善这一人群的结局。在这篇综述中，年龄作为ARDS的危险因素和预后指标以及可能导致这些因素的潜在潜在机制的当前临床证据进行了概述。此外，还讨论了年龄依赖性治疗方案和生物标志物的研究，以及针对这些潜在机制的未来前景。
Acute respiratory distress syndrome (ARDS) is associated with increased morbidity and mortality in the elderly population (≥65 years of age). Additionally, age is widely reported as a risk factor for the development of ARDS. However, the underlying pathophysiological mechanisms behind the increased risk of developing, and increased severity of, ARDS in the elderly population are not fully understood. This is compounded by the significant heterogeneity observed in patients with ARDS. With an aging population worldwide, a better understanding of these mechanisms could facilitate the development of therapies to improve outcomes in this population. In this review, the current clinical evidence of age as a risk factor and prognostic indicator in ARDS and the potential underlying mechanisms that may contribute to these factors are outlined. In addition, research on age-dependent treatment options and biomarkers, as well as future prospects for targeting these underlying mechanisms, are discussed.