Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex
Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex
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DOI：
10.1101/lm.804508
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发表时间：
2008-03-01
影响因子：
2
通讯作者：
Mitchell, Anna S.
中科院分区：
文献类型：
--
作者：
Baxter, Mark G.;Browning, Philip G. F.;Mitchell, Anna S.
额叶皮质和颞下皮质的手术分离严重损害视觉学习和记忆的许多方面，包括学习新的就地对象场景记忆问题，这是猴子的情景记忆模型。作为研究视觉学习和记忆中前额叶皮层专门化的一部分，我们测试了双侧腹外侧前额叶皮层消融的猴子在物体就位场景学习中的表现。这些猴子在场景学习方面相对于他们自己的术前表现有轻度受损，严重程度与双侧眶前额叶皮层消融的猴子相似。对反应类型的分析表明，有病变的猴子在学习过程中对负反馈的反应特别受损：手术后错误的增加仅限于对每个新问题的第一个反应的试验，基于试验和错误，是不正确的。在对双侧眶前额叶皮层消融的猴子的反应类型进行相同的分析时，没有观察到这种持续性的缺陷模式，这些猴子在正确和不正确的第一反应试验中受到同样的损害。这可能代表了腹外侧前额叶参与情景学习和记忆的一个特定特征。
Surgical disconnection of the frontal cortex and inferotemporal cortex severely impairs many aspects of visual learning and memory, including learning of new object-in-place scene memory problems, a monkey model of episodic memory. As part of a study of specialization within prefrontal cortex in visual learning and memory, we tested monkeys with bilateral ablations of ventrolateral prefrontal cortex in object-in-place scene learning. These monkeys were mildly impaired in scene learning relative to their own preoperative performance, similar in severity to that of monkeys with bilateral ablation of orbital prefrontal cortex. An analysis of response types showed that the monkeys with lesions were specifically impaired in responding to negative feedback during learning: The post-operative increase in errors was limited to trials in which the first response to each new problem, made on the basis of trial and error, was incorrect. This perseverative pattern of deficit was not observed in the same analysis of response types in monkeys with bilateral ablations of the orbital prefrontal cortex, who were equally impaired on trials with correct and incorrect first responses. This may represent a specific signature of ventrolateral prefrontal involvement in episodic learning and memory.