New noninvasive method for assessment of left ventricular rotation - Speckle tracking echocardiography
New noninvasive method for assessment of left ventricular rotation - Speckle tracking echocardiography
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DOI：
10.1161/circulationaha.104.531558
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发表时间：
2005-11-15
期刊：
影响因子：
37.8
通讯作者：
Smiseth, OA
中科院分区：
文献类型：
--
作者：
Helle-Valle, T;Crosby, J;Smiseth, OA
背景资料：左室扭转是由于心尖部和基底部反向旋转所致，已被认为是左室功能的敏感指标。在本研究中，我们介绍和验证斑点跟踪超声心动图（STE）作为一种方法，用于评估LV的旋转和torsion.Methods和结果：心尖和基底旋转STE测量从短轴图像的自动帧到帧跟踪的灰度斑点图案。旋转计算为9个区域相对于通过相同区域的最佳拟合圆的中心的平均角位移。作为参考方法，我们在基线、多巴酚丁胺输注和心尖缺血期间在麻醉犬中使用声显微测量法，并在健康人中使用磁共振成像（MRI）标记。在犬中，超声显微测量法和STE法测得的平均峰值顶端旋转分别为-3.7 +/-1.2度（+/-SD）和-4.1 +/-1.2度，基底旋转分别为1.9 +/-1.5度和2.0 +/-1.2度。两种方法的旋转度在多巴酚丁胺输注期间均增加（P <0.001）。冠状动脉左前降支闭塞时，两种方法的心尖旋转均减少（P <0.007），而基底旋转无变化。在健康人中，通过MRI标记和STE，心尖旋转分别为-11.6 +/-3.8度和-10.9 +/-3.3度，基底旋转分别为4.8 +/-1.7度和4.6 +/-1.3度。STE测量左室扭转与超声测声法（r = 0.94，P <0.001）和MRI（r = 0.85，P <0.001）具有良好的相关性和一致性。
Background: Left ventricular (LV) torsion is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of LV function. In the present study, we introduce and validate speckle tracking echocardiography (STE) as a method for assessment of LV rotation and torsion.Methods and Results: Apical and basal rotation by STE was measured from short-axis images by automatic frame-to-frame tracking of gray-scale speckle patterns. Rotation was calculated as the average angular displacement of 9 regions relative to the center of a best-fit circle through the same regions. As reference methods we used sonomicrometry in anesthetized dogs during baseline, dobutamine infusion, and apical ischemia, and magnetic resonance imaging (MRI) tagging in healthy humans. In dogs, the mean peak apical rotation was -3.7 +/- 1.2 degrees (+/- SD) and -4.1 +/- 1.2 degrees, and basal rotation was 1.9 +/- 1.5 degrees and 2.0 +/- 1.2 degrees by sonomicrometry and STE, respectively. Rotations by both methods increased (P < 0.001) during dobutamine infusion. Apical rotation by both methods decreased during left anterior descending coronary artery occlusion (P < 0.007), whereas basal rotation was unchanged. In healthy humans, apical rotation was -11.6 +/- 3.8 degrees and -10.9 +/- 3.3 degrees, and basal rotation was 4.8 +/- 1.7 degrees and 4.6 +/- 1.3 degrees by MRI tagging and STE, respectively. Torsion measurement by STE showed good correlation and agreement with sonomicrometry (r = 0.94, P < 0.001) and MRI (r = 0.85, P < 0.001).Conclusions: The present study demonstrates that regional LV rotation and torsion can be measured accurately by STE, suggesting a new echocardiographic approach for quantification of LV systolic function.