One-year experience with Tantalus™:: a new surgical approach to treat morbid obesity
One-year experience with Tantalus™:: a new surgical approach to treat morbid obesity
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DOI：
10.1381/096089206776945101
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发表时间：
2006-05-01
期刊：
影响因子：
2.9
通讯作者：
Ludvik, B
中科院分区：
文献类型：
--
作者：
Bohdjalian, A;Prager, G;Ludvik, B
背景资料：现代加工食品中热量密度的增加可能是肥胖症流行的一个重要因素，因为低体积、高热量的食物摄入可能会延迟已知诱导饱腹感的体积依赖性胃机械活动的激活。因此，我们假设，增强胃收缩的电刺激在早期阶段的膳食将减少食物摄入量和体重在病态肥胖subjects.Methods：这项研究是一项前瞻性的，非随机，开放标签，单中心试验。12名受试者（年龄36.1 ± 2.8岁，BMI 43.2 ± 2.7 kg/m2，体重128.8 ± 5.2 kg，平均值± SEM）接受了腹腔镜Tantalus（TM）系统植入术。植入了一个带有3个双极电极导线的脉冲发生器：2对在胃窦，第3对在胃底。该系统在第6周启动。结果：所有受试者均完成了最初的20周观察期，其中9例随访52周。激活Tantalus（TM）系统后，
Background: Increased caloric density in modern processed foods may be an important factor underlying the prevalence of obesity, because low-volume, high-caloric food intake may delay activation of volume-dependent gastric mechanical activity known to induce the feeling of fullness. We therefore hypothesized that enhancement of gastric contractions by electrical stimulation at an early stage of the meal will reduce food intake and body weight in morbidly obese subjects.Methods: The study was a prospective, non-randomized, open-label, single-center trial. 12 subjects (age 36.1 +/- 2.8 years, BMI 43.2 +/- 2.7 kg/m(2), weight 128.8 +/- 5.2 kg, means +/- SEM) underwent laparoscopic implantation with the Tantalus(TM) system. A pulse generator with 3 bipolar leads was implanted: 2 pairs in the antrum and a 3rd pair in the fundus. The system Was activated at week 6. All subjects were followed for 20 weeks and 9 of them for 52 weeks.Results: All subjects finished the initial 20-week observation period. following activation of the Tantalus(TM) System, a reduction (P