Latex beads as vehicles for the study of free radical processes in phagocytic cells.
Latex beads as vehicles for the study of free radical processes in phagocytic cells.
复制标题
乳胶珠作为研究吞噬细胞自由基过程的载体。
DOI：
10.1007/978-1-4684-5568-7_138
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Hedrick,CC
中科院分区：
文献类型：
--
作者：
Thomas,MJ;Hedrick,CC
The phagocytosing human polymorphonuclear leukocyte (PMN) generates large quantities of oxidants: superoxide (HO2̇and ·O2-, H2O2, and a chlorine-containing oxidant reputed to be hypochlorite. These oxidants are believed to aid in the killing of microorganisms since patients whose PMNs cannot undergo this “respiratory burst” suffer severe, recurrent infections. There appears to be good,1but not unequivocable evidence for the participation of superoxide in bacterial killing by the human PMN. Extensive2research has shown that ·O2-is neither a strong oxidant nor a strong reductant and, therefore, it is probably not a potent bactericide. The conjugate acid, HO$, should be sufficiently reactive3to attack many components of the bacterial cell. Since the human PMN phagosome generally is assumed to be acidic, the acid-base equilibrium will be shifted toward HO2̇. However, the disproportionation reaction rate increases rapidly as the pH approaches the pKaof HO2̇, 4.8.3It is not clear that attack on the susceptible bacterial cell components would be competitive with disproportionation.
