The sweet side of the cell cycle.
The sweet side of the cell cycle.
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DOI：
10.1042/bst20160145
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发表时间：
2017-04-15
影响因子：
3.9
通讯作者：
Slawson C
中科院分区：
文献类型：
--
作者：
Tan EP;Duncan FE;Slawson C
细胞分裂(有丝分裂)和配子产生(减数分裂)是正常器官发育的基本要求。哺乳动物的细胞周期由不同的检查点严格控制，确保完全和精确的染色体分离和复制。近年来，研究人员对了解O-GlcNAc如何调节细胞周期越来越感兴趣。O-GlcNAc翻译后修饰是单个β-N-乙酰氨基葡萄糖与胞内蛋白质的丝氨酸/苏氨酸残基的O-糖苷键。这种修饰对细胞环境中营养水平的变化很敏感，使O-GlcNAc成为能够影响细胞生长和增殖的营养传感器。大量研究表明，O-GlcN酰化在调节有丝分裂和减数分裂中是必不可少的，而O-GlcN酰化的缺失在生长细胞中是致命的。此外，O-GlcN酰化异常与癌症和染色体分离错误有关。在这篇综述中，我们将讨论O-GlcNAc如何控制细胞周期的不同方面，特别是有丝分裂和减数分裂。
Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for normal organismal development. The mammalian cell cycle is tightly regulated by different checkpoints ensuring complete and precise chromosomal segregation and duplication. In recent years, researchers have become increasingly interested in understanding how O-GlcNAc regulates the cell cycle. The O-GlcNAc post-translation modification is an O-glycosidic bond of a single β-N-acetylglucosamine sugar to serine/threonine residues of intracellular proteins. This modification is sensitive toward changes in nutrient levels in the cellular environment making O-GlcNAc a nutrient sensor capable of influencing cell growth and proliferation. Numerous studies have established that O-GlcNAcylation is essential in regulating mitosis and meiosis, while loss of O-GlcNAcylation is lethal in growing cells. Moreover, aberrant O-GlcNAcylation is linked with cancer and chromosomal segregation errors. In this review, we will discuss how O-GlcNAc controls different aspects of the cell cycle with a particular emphasis on mitosis and meiosis.