A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy.
A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy.
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DOI：
10.1097/ncc.0b013e3181ddc58c
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发表时间：
2010-07
期刊：
影响因子：
2.6
通讯作者：
Bank KA
中科院分区：
文献类型：
--
作者：
Dodd MJ;Cho MH;Miaskowski C;Painter PL;Paul SM;Cooper BA;Duda J;Krasnoff J;Bank KA
很少有研究评估癌症治疗期间和之后的个性化家庭运动处方。目的是评估以家庭为基础的运动训练干预的有效性，自我疲劳控制计划对癌症相关疲劳的管理。参与者（N=119）被随机分为三组：第1组（EE）在整个研究期间接受运动处方;第2组（CE）在完成癌症治疗后接受运动处方;第3组（CC）接受常规护理。患者完成Piper疲劳量表、一般睡眠障碍量表、流行病学中心抑郁量表和最严重疼痛强度量表。所有组都报告了轻度疲劳水平，睡眠障碍和轻度疼痛，但没有抑郁症。使用多水平回归分析，发现疲劳和疼痛的变化有显著的线性和二次趋势（即，分数随着时间的推移而增加，然后减少）。随着时间的推移，没有发现组间差异。一个显着的二次效应的轨迹睡眠障碍，但没有组间差异，随着时间的推移进行检测。没有发现抑郁症的显著时间或组效应。我们的家庭运动干预对癌症治疗相关的疲劳或相关症状没有影响。运动的最佳时机仍有待确定。临床医生需要意识到，一些体育活动总比没有好，在癌症治疗期间，运动是没有害处的。需要进一步分析，以检查坚持锻炼的情况。更频繁地评估疲劳、睡眠障碍、抑郁和疼痛可能会捕捉到运动的效果。
Few studies have evaluated an individualized home-based exercise prescription during and after cancer treatment. The purpose was to evaluate the effectiveness of a home-based exercise training intervention, the PRO-SELF FATIGUE CONTROL PROGRAM on the management of cancer related fatigue. Participants (N=119) were randomized into one of three groups: Group 1 (EE) received the exercise prescription throughout the study; Group 2 (CE) received their exercise prescription after completing cancer treatment; Group 3 (CC) received usual care. Patients completed the Piper Fatigue Scale, General Sleep Disturbance Scale, Center for Epidemiological Studies-Depression scale, and Worst Pain Intensity Scale. All groups reported mild fatigue levels, sleep disturbance and mild pain, but not depression. Using multilevel regression analysis significant linear and quadratic trends were found for change in fatigue and pain (i.e., scores increased, then decreased over time). No group differences were found in the changing scores over time. A significant quadratic effect for the trajectory of sleep disturbance was found, but no group differences were detected over time. No significant time or group effects were found for depression. Our home-based exercise intervention had no effect on fatigue or related symptoms associated with cancer treatment. The optimal timing of exercise remains to be determined. Clinicians need to be aware that some physical activity is better than none, and there is no harm in exercise as tolerated during cancer treatment. Further analysis is needed to examine the adherence to exercise. More frequent assessments of fatigue, sleep disturbance, depression, and pain may capture the effect of exercise.