InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment
InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment
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DOI：
10.1039/c2nr33024e
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发表时间：
2013-01-01
期刊：
影响因子：
6.7
通讯作者：
Pompa, Pier Paolo
中科院分区：
文献类型：
--
作者：
Brunetti, Virgilio;Chibli, Hicham;Pompa, Pier Paolo
通过比较水溶性 InP/ZnS 核/壳 QD 的体外（细胞培养）和体内（果蝇动物模型）毒性，我们发现水溶性 InP/ZnS 核/壳 QD 是生物应用中 CdSe/ZnS QD 的更安全替代品。通过选择具有相当物理和化学性质的量子点，我们发现这两种纳米材料的细胞摄取和定位实际上是相同的。 CdSe/ZnS QD 的毒性似乎与有毒 Cd2+ 离子的释放有关，实际上我们表明，尽管有两层 ZnS 壳，但颗粒核心仍存在 Cd2+ 离子的浸出。由于观察到从 InP/ZnS QD 核心浸出的 In(III) 离子数量几乎相同，因此本研究中揭示的它们的极低毒性表明，与镉相比，铟的内在毒性要低得多。
We show that water soluble InP/ZnS core/shell QDs are a safer alternative to CdSe/ZnS QDs for biological applications, by comparing their toxicity in vitro (cell culture) and in vivo (animal model Drosophila). By choosing QDs with comparable physical and chemical properties, we find that cellular uptake and localization are practically identical for these two nanomaterials. Toxicity of CdSe/ZnS QDs appears to be related to the release of poisonous Cd2+ ions and indeed we show that there is leaching of Cd2+ ions from the particle core despite the two-layer ZnS shell. Since an almost identical amount of In(III) ions is observed to leach from the core of InP/ZnS QDs, their very low toxicity as revealed in this study hints at a much lower intrinsic toxicity of indium compared to cadmium.