Identifying a candidate population for ovarian conservation in young women with clinical stage IB-IIB cervical cancer.
Identifying a candidate population for ovarian conservation in young women with clinical stage IB-IIB cervical cancer.
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DOI：
10.1002/ijc.31084
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发表时间：
2018-03-01
影响因子：
6.4
通讯作者：
Sugiyama T
中科院分区：
文献类型：
--
作者：
Matsuo K;Shimada M;Yamaguchi S;Kanao H;Nakanishi T;Saito T;Kamiura S;Iwata T;Mikami M;Sugiyama T
This study seeks to identify risk factors associated with ovarian metastasis and to characterize a population with minimum risk of ovarian metastasis in young women with stage IB–IIB cervical cancer. This was a nation-wide multicenter retrospective study in Japan examining consecutive cases of surgically-treated women with clinical stage IB–IIB cervical cancer who had oophorectomy at radical hysterectomy (n=5,697). Multivariable analysis was performed to identify independent risk factors for ovarian metastasis. Ovarian metastasis was seen in 70 (1.2%, 95% confidence interval 0.9–1.5) cases. In the entire cohort, adenocarcinoma, lympho-vascular space invasion, uterine corpus tumor invasion, and pelvic/para-aortic nodal metastases remained independent risk factors for ovarian metastasis (all, adjusted-p<0.05). In a sensitivity analysis of 3,165 women aged <50 years (ovarian metastasis, 1.0%), adenocarcinoma, parametrial tumor involvement, uterine corpus tumor involvement, and pelvic/para-aortic nodal metastases remained independent risk factors for ovarian metastasis (all, adjusted-P<0.05). In the absence of these five risk factors (representing 46.1% of women aged <50 years), the incidence of ovarian metastasis was 0.14%. With the presence of adenocarcinoma alone (representing 18.9% of women aged <50 years), the incidence of ovarian metastasis was 0.17% and was not associated with increased risk of ovarian metastasis compared to the subgroup without any risk factors (p=0.87). In conclusion, nearly two thirds of women aged <50 years with clinical stage IB–IIB cervical cancer had no risk factor for ovarian metastasis or had adenocarcinoma alone: these subgroups had ovarian metastasis rates of around 0.1% and may be a candidate population for ovarian conservation at surgical treatment.
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影响因子：
7.2
作者：
Matsuo K;Machida H;Shoupe D;Melamed A;Muderspach LI;Roman LD;Wright JD
通讯作者：
Wright JD
DOI：
10.1136/bmj.j372
发表时间：
2017-02-06
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Mytton J;Evison F;Chilton PJ;Lilford RJ
通讯作者：
Lilford RJ
影响因子：
3.3
作者：
Ebina, Yasuhiko;Yaegashi, Nobuo;Yoshikawa, Hiroyuki
通讯作者：
Yoshikawa, Hiroyuki
影响因子：
1.1
作者：
Sapre S;Thakur R
通讯作者：
Thakur R
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P