Solution structure of a BolA-like protein from Mus musculus
Solution structure of a BolA-like protein from Mus musculus
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DOI：
10.1110/ps.03401004
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发表时间：
2004-02-01
期刊：
影响因子：
8
通讯作者：
Yokoyama, S
中科院分区：
文献类型：
--
作者：
Kasai, T;Inoue, M;Yokoyama, S
bola样蛋白从原核生物到真核生物广泛保守。bola样蛋白似乎参与细胞增殖或细胞周期调节，但其分子功能尚不清楚。在这里，我们确定了小鼠bola样蛋白的结构。整体拓扑是alphabetbetaalphabetaalpha，其中beta(1)和beta(2)是反平行的，而beta(3)与beta(2)平行。该褶皱与II类KH褶皱相似，只是缺少了在KH褶皱中保守性较好的GXXG环。boia样蛋白中的保守残基聚集在蛋白质的一侧。
The BolA-like proteins are widely conserved from prokaryotes to eukaryotes. The BolA-like proteins seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. Here we determined the structure of a mouse BolA-like protein. The overall topology is alphabetabetaalphaalphabetaalpha, in which beta(1), and beta(2) are antiparallel, and beta(3) is parallel to beta(2). This fold is similar to the class II KH fold, except for the absence of the GXXG loop, which is well conserved in the KH fold. The conserved residues in the BoIA-like proteins are assembled on the one side of the protein.