NEW HYDRAZONE DERIVATIVES OF ADRIAMYCIN AND THEIR IMMUNOCONJUGATES - A CORRELATION BETWEEN ACID STABILITY AND CYTOTOXICITY
NEW HYDRAZONE DERIVATIVES OF ADRIAMYCIN AND THEIR IMMUNOCONJUGATES - A CORRELATION BETWEEN ACID STABILITY AND CYTOTOXICITY
复制标题
DOI：
10.1021/bc00009a001
复制
发表时间：
1991-05-01
影响因子：
4.7
通讯作者：
VYAS, DM
中科院分区：
文献类型：
--
作者：
KANEKO, T;WILLNER, D;VYAS, DM
合成了新的N-取代肼连接体，并合成了它们的阿霉素腙衍生物。将这些官能化的阿霉素衍生物与单克隆抗体5E 9缀合。研究了阿霉素从腙和从一些缀合物中的释放速率，并研究了它们与缀合物对5E 9阳性Daudi细胞的IC 50的关系。
New N-substituted hydrazine linkers were synthesized and their hydrazone derivatives of adriamycin were prepared. These functionalized adriamycin derivatives were conjugated with a monoclonal antibody, 5E9. The release rate of adriamycin from the hydrazones and from some of the conjugates was studied, and their relationship to the IC50's of the conjugate against 5E9-positive Daudi cells was investigated.