Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration
Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration
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脂肪水肿中的脂肪组织重塑：脂肪细胞死亡和同时再生
DOI：
10.1111/j.1600-0560.2009.01256.x
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发表时间：
2009
影响因子：
1.7
通讯作者：
K. Yoshimura
中科院分区：
文献类型：
--
作者：
H. Suga;J. Araki;N. Aoi;H. Kato;T. Higashino;K. Yoshimura
脂肪肿是一种病因不明的疾病，由于脂肪组织的皮下沉积，表现为双侧对称性的下肢肿大。在这里，我们描述了从一个典型的严重脂肿患者获得的脂肿组织和未受影响的脂肪组织的组织病理学特征。免疫组织化学分析显示脂肪组织退行性和再生性改变，分别表现为冠状结构(坏死性脂肪细胞被浸润性CD68+巨噬细胞包围，这是肥胖脂肪组织中常见的特征)和脂肪来源的干/祖/基质细胞(Ki67+CD34+细胞)增殖。这些发现表明脂肪组织中的脂肪生成增加，这可能进一步导致类似于肥胖的缺氧，导致脂肪细胞坏死和巨噬细胞募集。仅限于四肢，与全身性肥胖的区别需要在未来的研究中进一步阐明。
Lipedema is a disease with unknown etiology presenting as bilateral and symmetric enlargement of the lower extremities due to subcutaneous deposition of the adipose tissue. Here we describe the histopathological features of the lipedema tissue and nonaffected adipose tissue obtained from a typical patient with severe lipedema. Immunohistochemical analyses indicated degenerative and regenerative changes of the lipedema tissue, characterized by crown‐like structures (necrotizing adipocytes surrounded by infiltrating CD68+ macrophages; a feature commonly seen in obese adipose tissue) and proliferation of adipose‐derived stem/progenitor/stromal cells (Ki67+CD34+ cells), respectively. These findings suggested increased adipogenesis in the lipedema tissue, which may further lead to hypoxia similar to that seen in obesity, resulting in adipocyte necrosis and macrophage recruitment. The confinement to the lower extremities and the difference from systemic obesity warrants further elucidation in future studies.