Colorectal hepatic metastases: Detection with SPIO-enhanced breath-hold MR imaging - Comparison of optimized sequences
Colorectal hepatic metastases: Detection with SPIO-enhanced breath-hold MR imaging - Comparison of optimized sequences
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DOI：
10.1148/radiol.2283020376
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发表时间：
2003-09-01
期刊：
影响因子：
19.7
通讯作者：
Robinson, PJ
中科院分区：
文献类型：
--
作者：
Ward, J;Guthrie, JA;Robinson, PJ
目得：比较四个屏气磁共振（MR）成像序列的准确性，以建立最有效的超顺磁性氧化铁（SPIO）增强序列检测结直肠癌肝transferase.MATERIALS和METHODS：31例结直肠癌肝转移瘤患者进行T1加权梯度回波（GRE）和T2加权快速自旋回波（FSE）MR成像之前和SPIO增强后。四个序列进行了优化病变检测：T2加权FSE，多回波数据图像组合（MEDIC），T2加权GRE与11毫秒的回波时间（TE），和T2加权GRE与15毫秒的TE。由三名设盲观察员独立审查图像。每个序列的准确性进行了测量，通过使用替代自由响应接收器操作特性分析。所有结果均与手术、术中超声检查或组织病理学检查结果相关。结果：对比后T2加权GRE序列是最准确的，并显着优于对比后T2加权FSE和单独的非增强序列（P <0.05），上级。对于所有恶性或小于1 cm的病变，增强后序列的平均准确度分别为T2加权FSE 0.082和0.64，MEDIC 0.90和0.78，11毫秒TE的GRE 0.92和0.80，15毫秒TE的GRE 0.93和0.82，结论：优化SPIO增强T2加权梯度回波序列结合平扫T2加权快速自旋回波序列是最敏感的。屏气FSE增强后序列与单纯非增强序列相比，灵敏度没有提高。(C)RSNA，2003年。
PURPOSE: To compare the accuracy of four breath-hold magnetic resonance (MR) imaging sequences to establish the most effective superparamagnetic iron oxide (SPIO)-enhanced sequence for detection of colorectal hepatic metastases.MATERIALS AND METHODS: Thirty-one patients with colorectal hepatic metastases underwent T1-weighted gradient-echo (GRE) and T2-weighted fast spin-echo (FSE) MR imaging before and after SPIO enhancement. Four sequences were optimized for lesion detection: T2-weighted FSE, multiecho data image combination (MEDIC), T2-weighted GRE with an 11-msec echo time (TE), and T2-weighted GRE with a 15-msec TE. Images were reviewed independently by three blinded observers. The accuracy of each sequence was measured by using alternative free-response receiver operating characteristic analysis. All results were correlated with findings at surgery, intraoperative ultrasonography, or histopathologic examination. Differences between the mean results of the three observers were measured by using the Student t test.RESULTS: Postcontrast T2-weighted GRE sequences were the most accurate and were significantly superior to postcontrast T2-weighted FSE and unenhanced sequences alone (P < .05). For all lesions that were malignant or smaller than I cm, respectively, mean accuracies of postcontrast sequences were 0.082 and 0.64 for T2-weighted FSE, 0.90 and 0.78 for MEDIC, 0.92 and 0.80 for GRE with an 11-msec TE, 0.93 and 0.82 for GRE with a 15-msec TE, and 0.81 and 0.62 for unenhanced sequences.CONCLUSION: Optimized SPIO-enhanced T2-weighted GRE combined with unenhanced T2-weighted FSE MR sequences were the most sensitive. Breath-hold FSE postcontrast sequences offer no improvement in sensitivity compared with unenhanced sequences alone. (C) RSNA, 2003.