Human immune response, host genetics, and severity of disease.
Human immune response, host genetics, and severity of disease.
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人类免疫反应、宿主遗传学和疾病的严重程度。
DOI：
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发表时间：
2001
影响因子：
--
通讯作者：
A. Vaheri
中科院分区：
文献类型：
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作者：
O. Vapalahti;Å. Lundkvist;A. Vaheri
汉坦病毒感染在传播后的潜伏期约为2-4周，通常在出现症状时已产生有效的免疫反应，包括高水平的特异性抗体。这使得汉坦病毒感染的诊断相当简单；通常，汉坦病毒感染的诊断或排除可以通过单一测量汉坦病毒特异性IgM抗体来实现。然而，在特定地理区域选择正确的抗原或解释确切的感染因子时，应考虑汉坦病毒之间的交叉反应性（或缺乏交叉反应性）。除了有助于诊断外，症状与免疫反应的同时出现以及外周血和（如受感染的肺内皮）中各种细胞因子、炎症标志物和活化t细胞的早期存在，促使研究人员寻求该疾病的免疫发病机制。某些人类淋巴细胞抗原（HLA）单倍型与汉坦病毒病严重程度之间的关联进一步支持了这种机制。
Hantavirus infections have an incubation period of approximately 2–4 weeks after transmission and an effective immune response has usually already developed at the onset of symptoms, including high levels of specific antibodies. This makes the diagnostics of hantavirus infections rather straightforward; usually the diagnosis or exclusion of hantavirus infection can be achieved by a single measurement of hantavirus-specific IgM antibodies. However, cross-reactivities (or the lack of them) between hantaviruses should be taken into consideration when choosing the right antigen in a given geographical area, or when interpreting the exact infecting agent. In addition to being helpful for diagnostics, the coinciding onset of symptoms with the immune response together with early presence of various cytokines,inflammation markers, and activated T-cells in peripheral blood and in, e.g., infected lung endothelia, has prompted researchers to seek immunopathogenetic mechanisms for the disease. Such mechanisms are further supported by the association between certain human lymphocyte antigen (HLA) haplotypes and severity of the hantavirus disease.
影响因子：
6
作者：
S. Zaki;P. Greer;L. Coffield;C. Goldsmith;K. B. Nolte;K. Foucar;R. Feddersen;R. Zumwalt;G. Miller;Ali S Khan;P. Rollin;T. Ksiazek;S. Nichol;B. Mahy;C. Peters
通讯作者：
S. Zaki;P. Greer;L. Coffield;C. Goldsmith;K. B. Nolte;K. Foucar;R. Feddersen;R. Zumwalt;G. Miller;Ali S Khan;P. Rollin;T. Ksiazek;S. Nichol;B. Mahy;C. Peters
DOI：
10.1073/pnas.95.12.7074
发表时间：
1998-06-09
影响因子：
11.1
作者：
Gavrilovskaya, IN;Shepley, M;Mackow, ER
通讯作者：
Mackow, ER