The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy.
The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy.
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DOI：
10.2147/jir.s334996
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发表时间：
2021
影响因子：
4.5
通讯作者：
Nie X
中科院分区：
文献类型：
--
作者：
Deng J;Liu Y;Liu Y;Li W;Nie X
糖尿病肾病（DN）是糖尿病晚期常见的微血管并发症。目前，DN的病因和发病机制尚不清楚。尽管如此，现有证据显示其发展与代谢、氧化应激、细胞因子相互作用、遗传因素和肾微血管疾病有关。糖尿病肾病可导致蛋白尿、水肿和高血压等并发症。在严重的情况下，它可能导致危及生命的并发症，如肾衰竭。1型糖尿病、高血压、高蛋白质摄入和吸烟的患者发生DN的风险更高。成纤维细胞生长因子（FGF）调节正常发育所必需的几个人类过程。尽管FGF参与了DN的病理发展，但其潜在机制尚不清楚。本文就FGF在DN发生发展中的作用作一综述。此外，FGF与代谢，炎症，氧化应激和纤维化的背景下，DN的关联进行了讨论。本综述的结果有望加深我们对DN的理解，并为开发有效的预防和治疗该病提供思路。
Diabetic nephropathy (DN) is a common microvascular complication in the late stages of diabetes. Currently, the etiology and pathogenesis of DN are not well understood. Even so, available evidence shows its development is associated with metabolism, oxidative stress, cytokine interaction, genetic factors, and renal microvascular disease. Diabetic nephropathy can lead to proteinuria, edema and hypertension, among other complications. In severe cases, it can cause life-threatening complications such as renal failure. Patients with type 1 diabetes, hypertension, high protein intake, and smokers have a higher risk of developing DN. Fibroblast growth factor (FGF) regulates several human processes essential for normal development. Even though FGF has been implicated in the pathological development of DN, the underlying mechanisms are not well understood. This review summarizes the role of FGF in the development of DN. Moreover, the association of FGF with metabolism, inflammation, oxidative stress and fibrosis in the context of DN is discussed. Findings of this review are expected to deepen our understanding of DN and generate ideas for developing effective prevention and treatments for the disease.