Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication
Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication
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DOI：
10.1046/j.1365-2036.2002.01335.x
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发表时间：
2002-09-01
影响因子：
7.6
通讯作者：
Lin, MD
中科院分区：
文献类型：
--
作者：
Sheu, BS;Wu, JJ;Lin, MD
目的：目的：研究补充含乳酸杆菌和双歧杆菌的酸奶（AB酸奶）对幽门螺杆菌根除的影响。将幽门螺杆菌感染的患者随机分为三联加酸奶组或三联单用组，分别接受1周的三联治疗，同时补充和不补充AB-酸奶。三联加酸奶组在三联治疗后继续服用AB酸奶4周。8周后，对患者进行H.根除幽门随机选择22例患者，每组11例，在入组时，在第一周和第五周提供粪便样本，用于评估厌氧菌中双歧杆菌的百分比。pylori根除率明显高于单纯三联治疗组（91% vs. 78%，P < 0.05）。符合方案H.两组的幽门螺杆菌根除率相似（93.5% vs. 89%，P = N.S.）。结论：补充AB酸奶可提高H.幽门螺杆菌，并能恢复三联治疗后粪便中双歧杆菌的消耗。
Aim: To test whether supplements of Lactobacillus- and Bifidobacterium-containing yogurt (AB-Yogurt) affect the success of Helicobacter pylori eradication.Methods: One hundred and sixty H. pylori-infected patients were randomized into a triple-plus-yogurt group or a triple-only group, receiving 1 week of triple therapy with and without supplements of AB-Yogurt, respectively. In the triple-plus-yogurt group, AB-Yogurt was continued for 4 weeks after triple therapy. Eight weeks later, patients were assessed for the success of H. pylori eradication. The stool samples of 22 randomly selected patients, 11 from each group, were provided on enrolment, at the first week and at the fifth week for evaluation of the percentage of Bifidobacterium in anaerobes.Results: By intention-to-treat analysis, the triple-plus-yogurt group had a higher H. pylori eradication rate than the triple-only group (91% vs. 78%, P < 0.05). The per protocol H. pylori eradication rates were similar for both groups (93.5% vs. 89%, P = N.S.). Only patients supplemented with AB-Yogurt showed restoration of the percentage of Bifidobacterium in the anaerobes of stools at the fifth week to the level in the stools on enrolment.Conclusions: Supplement with AB-Yogurt can improve the intention-to-treat eradication rates of H. pylori, and can restore the depletion of Bifidobacterium in stools after triple therapy.