Alcohol misuse and psychosocial outcomes in young adulthood: Results from a longitudinal birth cohort studied to age 30
Alcohol misuse and psychosocial outcomes in young adulthood: Results from a longitudinal birth cohort studied to age 30
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DOI：
10.1016/j.drugalcdep.2013.07.015
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发表时间：
2013-12-01
影响因子：
4.2
通讯作者：
Horwood, L. John
中科院分区：
文献类型：
--
作者：
Fergusson, David M.;Soden, Joseph M.;Horwood, L. John
目的：本研究在一个新西兰出生队列中，考察了21岁至30岁期间酒精滥用/依赖症状的测量指标与一系列社会心理结果之间的关联。
方法：结果测量指标包括犯罪行为、家庭暴力和关系不稳定、性冒险及后果、心理健康以及其他不良健康和适应结果等方面的测量。使用广义估计方程模型计算了酒精滥用的三级分类（无症状、亚临床症状水平、符合酒精依赖标准）与21 - 30岁期间每个结果之间的双变量关联。然后，使用条件固定效应回归模型，并辅以时间动态协变量因素，对未观察到的混杂来源进行调整。对两组模型都计算了归因风险（AR）的估计值。
结果：酒精滥用与15个结果测量指标中的每一个都存在统计学上显著（p <.05）的双变量关联，AR的估计值范围从7.4%到46.5%。对未观察到的固定效应进行调整通常会降低这些关联的程度；然而，调整后，15个关联中有12个仍然具有统计学显著性（p <.05）。对固定效应调整后的AR估计值范围从3.6%到44.3%。
结论：结果表明，酒精滥用与一系列不良社会心理结果之间存在普遍且持久的联系。该年龄组个体中酒精滥用水平的降低可能会大幅降低危险饮酒水平所带来的个人和社会总成本。（C）2013爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: This study examined the associations between measures of alcohol abuse/dependence symptoms and a range of psychosocial outcomes from ages 21 to 30 in a New Zealand birth cohort.Methods: Outcome measures included measures of: criminal offending, family violence and relationship instability, sexual risk-taking and consequences, mental health, and other adverse health and adjustment outcomes. Bivariate associations between a three-level classification of alcohol misuse (no symptoms, subclinical level of symptoms, met criteria for alcohol dependence) and each outcome during the period 21-30 years were computed using Generalised Estimating Equation models. These associations were then adjusted for non-observed sources of confounding using conditional fixed effects regression modelling, augmented by time-dynamic covariate factors. For both sets of models estimates of the attributable risk (AR) were computed.Results: There were statistically significant (p < .05) bivariate associations between alcohol misuse and each of the fifteen outcome measures, with estimates of the AR ranging from 7.4% to 46.5%. Adjustment for non-observed fixed effects generally reduced the magnitude of these associations; however, after adjustment, 12 of the 15 associations remained statistically significant (p < .05). Estimates of the AR after adjustment for fixed effects ranged from 3.6% to 44.3%.Conclusions: The results suggest that there are pervasive and persistent linkages between alcohol misuse and a range of adverse psychosocial outcomes. A reduction in levels of alcohol misuse amongst individuals of this age group could reduce substantially the overall level of personal and societal cost of hazardous levels of alcohol consumption. (C) 2013 Elsevier Ireland Ltd. All rights reserved.