Simple physical performance measures and vascular health in late midlife women: the Study of Women's Health across the nation
Simple physical performance measures and vascular health in late midlife women: the Study of Women's Health across the nation
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DOI：
10.1016/j.ijcard.2014.12.042
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发表时间：
2015-03-01
影响因子：
3.5
通讯作者：
Sternfeld, Barbara
中科院分区：
文献类型：
--
作者：
El Khoudary, Samar R.;Chen, Hsiang-Yu;Sternfeld, Barbara
背景资料：体能指标已被证明主要在老年人群中预测死亡率和心血管疾病（CVD）事件。我们评估了是否物理性能的措施与血管健康指数（颈动脉内膜中层厚度（cIMT），外膜直径（cAD）和颈动脉斑块）在一个大样本的多种族，中年晚期women.Methods：参与者的研究妇女的健康全国免费的心血管疾病和谁有颈动脉超声评估在第12次年度访问进行了评估。身体功能（PF）的措施，在访问12包括：平均40英尺步行速度和平均所需的时间坐到站assessment.Results：共1103名妇女（53.7%白色，30.5%黑人，15.9%中国）年龄59.6 +/- 2.7年访问12，被列入。在根据研究地点、种族、当前年龄、绝经状态和收缩压调整的模型中，较慢的步行速度和从坐到站所需的较长时间与较宽的cAD、较厚的cIMT和较高的颈动脉斑块负荷水平的概率显著相关（所有P值< 0.05）。在对CVD风险因素、药物和体力活动进行额外调整后，步行速度和cAD之间的相关性以及坐立所需时间和cAD之间的相关性分别保持显著（P = 0.04）或轻微显著（P = 0.07）。然而，PF措施和cIMT和斑块负担之间的关联在很大程度上解释了传统的CVD risk factors.Conclusions：目前的研究表明，在简单的客观PF测试的性能较差可能是一个早期指标的血管结构变化，之前的血管疾病的妇女在中年晚期。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Background: Physical performance measures have been shown to predict mortality and incident cardiovascular disease (CVD) mainly in elderly populations. We evaluated whether physical performance measures are associated with vascular health indices (carotid intima-media thickness (cIMT), adventitial diameter (cAD) and carotid plaque) in a large sample of multi-ethnic, late midlife women.Methods: Participants from the Study of Women's Health Across the Nation free of CVD and who had carotid ultrasound assessed at the 12th annual visit were evaluated. Physical function (PF) measures at visit 12 included: average 40-foot walking speed and average time needed for sit-to-stand assessment.Results: A total of 1103 women (53.7% White, 30.5% Black, 15.9% Chinese) aged 59.6 +/- 2.7 years at visit 12, were included. In models adjusted for study site, race, current age, menopausal status and systolic blood pressure, slower walking speed and longer time needed for sit-to-stand were significantly associated with wider cAD, thicker cIMT and a higher probability of a high level of carotid plaque burden (all P-values < 0.05). Associations between walking speed and cAD, and between time needed for sit-to-stand and cAD, remained significant (P = 0.04) or marginally significant (P = 0.07), respectively, after additional adjustment for CVD risk factors, medications and physical activity. However, the associations between PF measures and cIMT and plaque burden were largely explained by traditional CVD risk factors.Conclusions: The current study suggests that worse performance in simple objective PF tests may be an early indicator of vascular structural changes that precede vascular disease among women at late midlife. (C) 2014 Elsevier Ireland Ltd. All rights reserved.