Prevalence of acute kidney injury and prognostic significance in patients with acute myocarditis.
Prevalence of acute kidney injury and prognostic significance in patients with acute myocarditis.
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DOI：
10.1371/journal.pone.0048055
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lai HS
中科院分区：
文献类型：
--
作者：
Yang YW;Wu CH;Ko WJ;Wu VC;Chen JS;Chou NK;Lai HS
心肌炎是心肌的炎症。这种情况通常与疾病的快速进展有关，并经常导致严重休克。肾功能受损是终末器官灌注受损的结果，在危重患者中非常普遍。本研究的目的是评估急性肾损伤（阿基）的发生率，并确定阿基与急性心肌炎患者预后之间的关系。这项回顾性研究回顾了1996年至2011年期间101例急性心肌炎患者的病历。其中60例患者（59%）在住院后48小时内发生阿基。在多变量分析中，阿基定义为AKIN 3期（p = 0.007）和SOFA评分（p =0.03）被确定为院内死亡率的预测因子。 根据AKIN分期分类的入院时SOFA评分估计风险的条件效应图显示，SOFA评分高的AKIN 3期患者的院内死亡风险最高。在急性心肌炎患者中，阿基定义为AKIN 3期和SOFA评分升高与不良结局相关。AKIN分级是一种简单、可重复、易于应用的评估工具，能够提供与急性心肌炎患者临床预后相关的客观信息。
Myocarditis is an inflammation of the myocardium. The condition is commonly associated with rapid disease progression and often results in profound shock. Impaired renal function is the result of impairment in end-organ perfusion and is highly prevalent among critically ill patients. The aim of this study was to evaluate the incidence of acute kidney injury (AKI) and identify the relationship between AKI and the prognosis of patients with acute myocarditis. This retrospective study reviewed the medical records of 101 patients suffering from acute myocarditis between 1996 and 2011. Sixty of these patients (59%) developed AKI within 48 hours of being hospitalized. AKI defined as AKIN stage 3 (p = 0.007) and SOFA score (p = 0.03) were identified as predictors of in-hospital mortality in multivariate analysis. The conditional effect plot of the estimated risk against SOFA score upon admission categorized according to the AKIN stages showed that the risk of in-hospital mortality was highest among patients in AKIN stage 3 with a high SOFA score. Among patients with acute myocarditis, AKI defined as AKIN stage 3 and elevated SOFA score were associated with unfavorable outcomes. AKIN classification is a simple, reproducible, and easily applied evaluation tool capable of providing objective information related to the clinical prognosis of patients with acute myocarditis.
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急性肾脏损伤的步枪标准与重症患者的医院死亡率有关：一项队列分析。
影响因子：
15.1
作者：
Hoste, Eric A. J.;Clermont, Gilles;Kersten, Alexander;Venkataraman, Ramesh;Angus, Derek C.;De Bacquer, Dirk;Kellum, John A.
通讯作者：
Kellum, John A.
DOI：
10.1186/cc10241
发表时间：
2011
期刊：
Critical care (London, England)
影响因子：
--
作者：
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通讯作者：
Timsit JF
影响因子：
13.6
作者：
Huang, Tao-Min;Wu, Vin-Cent;Wu, Kwan-Dun
通讯作者：
Wu, Kwan-Dun
影响因子：
4.5
作者：
Toma, Tudor;Abu-Hanna, Ameen;Bosman, Robert-Jan
通讯作者：
Bosman, Robert-Jan
影响因子：
1.5
作者：
Badreldin, A. M. A.;Doerr, F.;Hekmat, K.
通讯作者：
Hekmat, K.