PRENATAL LEAD-EXPOSURE IN RELATION TO GESTATIONAL-AGE AND BIRTH-WEIGHT - A REVIEW OF EPIDEMIOLOGIC STUDIES
PRENATAL LEAD-EXPOSURE IN RELATION TO GESTATIONAL-AGE AND BIRTH-WEIGHT - A REVIEW OF EPIDEMIOLOGIC STUDIES
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DOI：
10.1002/ajim.4700260103
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发表时间：
1994-07-01
影响因子：
3.5
通讯作者：
HERTZPICCIOTTO, I
中科院分区：
文献类型：
--
作者：
ANDREWS, KW;SAVITZ, DA;HERTZPICCIOTTO, I
虽然多年来人们已经认识到工作场所高水平铅暴露对妊娠结局的不利影响，但目前普遍遇到的较低社区铅暴露水平的影响尚不确定。本文综述了流行病学文献，并讨论了相关的方法学问题和研究间变异的可能来源。作者得出结论，产前铅暴露不太可能增加胎膜早破的风险，但似乎会增加早产的风险。就婴儿而言，产前铅暴露是否会降低胎龄尚不清楚。产前铅暴露似乎也与出生体重降低有关，但结果因研究设计和混淆控制程度而异。调整胎龄，一个可能与出生体重-铅暴露相关的混杂因素，并没有产生更清晰的结果。(C) 1994 Wiley-Liss, Inc。
Although the adverse effect on pregnancy outcomes at high levels of lead exposure in the workplace has been recognized for years, there is uncertainty regarding the impact of exposure at the lower community exposure levels commonly encountered today. This review summarizes the epidemiologic literature and discusses pertinent methodologic issues and possible sources of interstudy variation. The authors conclude that prenatal lead exposure is unlikely to increase the risk of premature membrane rupture but does appear to increase the risk of preterm delivery. Whether prenatal lead exposure decreases gestational age in terms of infants is unclear. Prenatal lead exposure also appears to be associated with reduced birth weight, but results vary in relation to study design and degree of control for confounding. Adjustment for gestational age, a possible confounder of the birth weight-lead exposure association, did not yield clearer results. (C) 1994 Wiley-Liss, Inc.