Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera
Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera
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DOI：
10.1021/np980129a
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发表时间：
1998-10-01
影响因子：
5.1
通讯作者：
Hamann, MT
中科院分区：
文献类型：
--
作者：
Shen, XY;Perry, TL;Hamann, MT
通过结构引导分离鉴定治疗艾滋病机会性感染的先导化合物，从伯利兹采集的加勒比海绵松叶松中分离出一种新的对称吡咯二聚体debromosceptrin(1)的二盐酸盐和两种已知的吡咯类似物（2和3）。通过对光谱数据的分析，对其结构进行了鉴定。对化合物1 ~ 3进行了N-15光谱数据赋值。化合物2和3对结核分枝杆菌有微弱抑制作用。
As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas conifera collected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. N-15 spectral data assignments were made for compounds 1-3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.