Microcomputed tomography imaging of skeletal development and growth.
Microcomputed tomography imaging of skeletal development and growth.
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DOI：
10.1002/bdrc.20016
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发表时间：
2004-09-01
期刊：
影响因子：
--
通讯作者：
Duvall, Craig
中科院分区：
文献类型：
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作者：
Guldberg, Robert E;Lin, Angela S P;Duvall, Craig
骨骼形成是一个精心安排和动态的过程，最终形成高度可变和复杂的矿化结构，这些结构为其功能进行了优化。虽然细胞和分子生物学研究在了解骨形成模式是如何调控方面取得了巨大的进展，但诸如微型计算机断层扫描(Micro-CT)之类的高分辨率成像技术可以提供关于早期骨骼发育和出生后生长过程中三维(3D)骨骼形态和密度的渐进性变化的补充定量信息。此外，最近发展起来的体内微型CT系统有望成为一种强大而有效的工具，用于非侵入性监测正常的骨骼形成，以及评估遗传或环境操作的效果。本文重点介绍了利用显微CT成像和分析来更好地了解正常和异常骨骼发育和生长的研究进展。
Skeletogenesis is an exquisitely orchestrated and dynamic process, culminating in the formation of highly variable and complex mineralized structures that are optimized for their function. While cellular and molecular biology studies have provided tremendous recent progress toward understanding how patterns of bone formation are regulated, high resolution imaging techniques such as microcomputed tomography (micro-CT) can provide complementary quantitative information about the progressive changes in three-dimensional (3-D) skeletal morphology and density that occur during early skeletal development and postnatal growth. Furthermore, recently developed in vivo micro-CT systems promise to be a powerful and efficient tool for noninvasively monitoring normal skeletogenesis, as well as for evaluating the effects of genetic or environmental manipulation. This review focuses on the use of micro-CT imaging and analysis to better understand normal and abnormal skeletal development and growth.