Fetal origins of adult hypertension: a renal mechanism?
Fetal origins of adult hypertension: a renal mechanism?
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成人高血压的胎儿起源：肾脏机制？
DOI：
10.1097/00041552-200007000-00014
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发表时间：
2000
影响因子：
3.2
通讯作者：
Woods,LL
中科院分区：
文献类型：
--
作者：
Woods,LL
众所周知，心血管疾病的病因至少包括两个组成部分：遗传因素和“生活方式”或环境因素。然而，过去十年积累的流行病学证据越来越有力地证明了第三个组成部分，即发育期间（即出生前）的环境条件，在影响个体总体心血管风险方面的重要作用。婴儿所接触的产前环境中的因素可能会导致体内特定组织的结构和功能发生永久性变化。虽然这些变化在短期内可能有价值，因为它们可以让人们存活到出生，但从长远来看，这些变化是适应不良的，因为它们使个体容易患上一系列成人疾病。阐明这种针对成人心血管疾病的围产期“编程”发生的可能生理和形态机制的实验数据现在才刚刚出现。然而，肾素-血管紧张素系统及其在肾脏发育中发挥的重要作用，可能在导致心血管疾病，特别是高血压的轨迹中发挥着核心作用。
It is well-recognized that the etiology of cardiovascular disease includes at least two components: a genetic component and a ‘lifestyle’or environmental component. However, epidemiological evidence accumulating over the past decade has provided an increasingly strong case for the important involvement of a third component, that of environmental conditions during development (ie before birth), in contributing to an individual's overall cardiovascular risk. Factors in the prenatal environment to which a baby is exposed can cause permanent changes in the structure and function of specific tissues in the body. Although perhaps valuable in the short term in that they allow survival until birth, these changes are maladaptive in the long term because they predispose the individual to an array of adult diseases. Experimental data elucidating the possible physiological and morphological mechanisms by which this perinatal ‘programming’for adult cardiovascular disease occurs are only just now becoming available. However, it appears that the renin-angiotensin system, and the important role it plays in renal development, may be central in setting the trajectory that leads to cardiovascular disease, and in particular hypertension.