Wall enhancement on high-resolution magnetic resonance imaging may predict an unsteady state of an intracranial saccular aneurysm
Wall enhancement on high-resolution magnetic resonance imaging may predict an unsteady state of an intracranial saccular aneurysm
复制标题
高分辨率磁共振成像的壁增强可以预测颅内囊状动脉瘤的不稳定状态。
DOI：
10.1007/s00234-016-1729-3
复制
发表时间：
2016-10-01
期刊：
影响因子：
2.8
通讯作者：
Zhang, Hong-Qi
中科院分区：
文献类型：
--
作者：
Hu, Peng;Yang, Qi;Zhang, Hong-Qi
据报道，动脉瘤壁在动脉瘤的形成、发展甚至破裂中起关键作用。我们使用高分辨率磁共振成像（HRMRI）研究动脉瘤壁，以确定炎症侵袭的证据，并确定其与动脉瘤行为的关系。本研究纳入了2013年7月至2014年6月期间使用HRMRI进行前瞻性评价的颅内动脉瘤患者。确定动脉瘤壁强化和炎症浸润的证据。此外，动脉瘤壁增强与动脉瘤大小和症状之间的关系，包括破裂的动脉瘤、表现为占位效应的巨大未破裂颅内动脉瘤（UIA）、进行性生长的动脉瘤和与神经系统症状相关的动脉瘤，进行了统计分析。14个动脉瘤瘤壁强化，其中破裂6个，未破裂8个。炎症证据直接通过组织学研究确定，间接通过术中调查和临床过程。统计学分析表明动脉瘤壁增强与动脉瘤大小之间无显著相关性。然而，壁增强与动脉瘤症状之间存在强相关性，Kappa值为0.86（95%CI 0.68-1）。HRMRI上的动脉瘤壁增强可能是炎性改变的迹象。症状性动脉瘤在HRMRI上表现为壁增强。壁增强与症状性动脉瘤具有高度一致的相关性。因此，HRMRI上的壁增强可能预测颅内囊状动脉瘤的不稳定状态。
The aneurysm wall has been reported to play a critical role in the formation, development, and even rupture of an aneurysm. We used high-resolution magnetic resonance imaging (HRMRI) to investigate the aneurysm wall in an effort to identify evidence of inflammation invasion and define its relationship with aneurysm behavior.Patients with intracranial aneurysms who were prospectively evaluated using HRMRI between July 2013 and June 2014 were enrolled in this study. The aneurysm's wall enhancement and evidence of inflammation invasion were determined. In addition, the relationship between aneurysm wall enhancement and aneurysm size and symptoms, including ruptured aneurysms, giant unruputred intracranial aneurysms (UIAs) presenting as mass effect, progressively growing aneurysms, and aneurysms associated with neurological symptoms, was statistically analyzed.Twenty-five patients with 30 aneurysms were available for the current study. Fourteen aneurysms showed wall enhancement, including 6 ruptured and 8 unruptured aneurysms. Evidence of inflammation was identified directly through histological studies and indirectly through intraoperative investigations and clinical courses. The statistical analysis indicated no significant correlation between aneurysm wall enhancement and aneurysm size. However, there was a strong correlation between wall enhancement and aneurysm symptoms, with a kappa value of 0.86 (95 % CI 0.68-1).Aneurysm wall enhancement on HRMRI might be a sign of inflammatory change. Symptomatic aneurysms exhibited wall enhancement on HRMRI. Wall enhancement had a high consistent correlation of symptomatic aneurysms. Therefore, wall enhancement on HRMRI might predict an unsteady state of an intracranial saccular aneurysm.