Prostatic signet-ring cell carcinoma: Case report and literature review
Prostatic signet-ring cell carcinoma: Case report and literature review
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DOI：
10.1046/j.1440-1827.1999.00876.x
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发表时间：
1999-05-01
影响因子：
2.2
通讯作者：
Enzan, H
中科院分区：
文献类型：
--
作者：
Kuroda, N;Yamasaki, I;Enzan, H
前列腺印戒细胞癌 (SRCC) 是一种非常罕见的肿瘤，迄今为止仅报告了 38 例。本文报道第39例前列腺SRCC，其印戒细胞内含有少量中性粘蛋白、前列腺特异性抗原(PSA)和前列腺特异性酸性磷酸酶(PSAP)。还发现一些胞质内管腔源自形成肿瘤腺体的癌细胞管腔膜的浅或深内陷。使用免疫组织化学，抗细胞角蛋白 7 和 20 的单克隆抗体以及 PSA 和 PSAP 的组合可能有助于区分前列腺原发性 SRCC 与源自胃肠道的转移性 SRCC。
Signet-ring cell carcinoma (SRCC) of the prostate is a very rare neoplasm and there have been only 38 cases reported to date. Here the 39th case of prostatic SRCC containing a small amount of neutral mucin, prostatic specific antigen (PSA) and prostatic specific acid phosphatase (PSAP) in the signet-ring cells is reported. It was also found that some intracytoplasmic lumina were derived from the shallow or deep invagination of luminal membranes of cancer cells that formed the neoplastic glands. Using immunohistochemistry, a combination of monoclonal antibodies against cytokeratins 7 and 20 as well as PSA and PSAP may be useful in differentiating prostatic primary SRCC from metastatic SRCC originating in the gastrointestinal tract.