Antiarrhythmic effects of MS-551, a new class III antiarrhythmic agent, on canine models of ventricular arrhythmia.
Antiarrhythmic effects of MS-551, a new class III antiarrhythmic agent, on canine models of ventricular arrhythmia.
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MS-551（一种新型 III 类抗心律失常药物）对犬室性心律失常模型的抗心律失常作用。
DOI：
10.1254/jjp.58.107
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
T. Katakami
中科院分区：
文献类型：
--
作者：
J. Kamiya;M. Ishii;T. Katakami
在三种不同的犬室性心律失常模型中评估了MS-551的抗心律失常作用，MS-551延长心脏动作电位持续时间，而不影响动作电位的最大上行速度：1）心肌梗死后3-5天电刺激诱发的室性心动过速（VT），（2）冠脉结扎后24-48小时自发性室性心律失常;（3）洋地黄引起的室性心律失常。静脉注射MS-551（0.1-1 mg/kg）可降低13只犬中10只对心肌梗死后3-5天向室间隔递送程序电刺激（PES）诱发的VT或室颤的易感性。口服MS-551（3 mg/kg）也降低了7/10只清醒的梗死后犬对PES诱发的VT的敏感性。同时，静脉（0.1-1 mg/kg）或经口（3 mg/kg）给予MS-551分别使心室有效不应期（ERP）延长7 +/- 1% - 17 +/- 3%或13 +/-2%。类似地，d-索他洛尔（0.3-3 mg/kg，i. v.和10 mg/kg，p.o.）降低了VT的易感性，ERP增加。然而，MS-551（1和10 mg/kg，i. v.）不能抑制犬二级冠脉结扎心律失常和洋地黄心律失常。这些结果表明，MS-551是一种纯III类抗心律失常药物，可有效治疗危及生命的折返性快速性心律失常，但对自律性心律失常无效。
The antiarrhythmic effects of MS-551, which prolongs cardiac action potential duration without affecting the maximum upstroke velocity of the action potential, were assessed in three different canine ventricular arrhythmia models: 1) ventricular tachycardia (VT) induced by electrical stimuli 3-5 days after myocardial infarction, 2) spontaneous ventricular tachyarrhythmias 24-48 hr after two-stage coronary ligation and 3) ventricular tachyarrhythmias induced by digitalis. Intravenous administration of MS-551 (0.1-1 mg/kg) decreased the susceptibility in 10 dogs out of 13 to VT or ventricular fibrillation evoked by programmed electrical stimulation (PES) delivered to the ventricular septum 3-5 days after myocardial infarction. Oral administration of MS-551 (3 mg/kg) also decreased the susceptibility to VT evoked by PES in 7 out of 10 conscious postinfarction dogs. Concurrently, intravenous (0.1-1 mg/kg) or oral (3 mg/kg) administration of MS-551 produced increases in the ventricular effective refractory periods (ERP) by 7 +/- 1% - 17 +/- 3% or 13 +/- 2%, respectively. Similarly, d-sotalol (0.3-3 mg/kg, i.v. and 10 mg/kg, p.o.) decreased the susceptibility to VT with increased ERP. However, MS-551 (1 and 10 mg/kg, i.v.) failed to inhibit both canine two-stage coronary ligation arrhythmia and digitalis arrhythmia. These results suggest that MS-551 is a pure class III antiarrhythmic drug which may be effective in the treatment of life-threatening reentrant tachyarrhythmias, but not in automaticity arrhythmias.
清醒犬心肌梗塞后折返性室性心律失常：甲苯磺酸溴苄酯抑制。
DOI：
--
发表时间：
1981
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Patterson,E;Gibson,JK;Lucchesi,BR
通讯作者：
Lucchesi,BR
氯非铵在实验犬模型中的抗心律失常和电生理作用。
影响因子：
5
作者：
Kopia,GA;Eller,BT;Patterson,E;Shea,MJ;Lucchesi,BR
通讯作者：
Lucchesi,BR
索他洛尔左旋和右旋异构体的抗心律失常和抗纤颤作用。
影响因子：
3
作者：
Lynch,JJ;Wilber,DJ;Montgomery,DG;Hsieh,TM;Patterson,E;Lucchesi,BR
通讯作者：
Lucchesi,BR