A 50 year history of technologies that drove discovery in eukaryotic transcription regulation
A 50 year history of technologies that drove discovery in eukaryotic transcription regulation
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DOI：
10.1038/s41594-019-0288-9
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发表时间：
2019-09-01
影响因子：
16.8
通讯作者：
Lis, John T.
中科院分区：
文献类型：
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作者：
Lis, John T.
转录调控是生物体发育和动态平衡的关键。控制人类细胞中20,000个基因的表达需要数百种蛋白质通过复杂的多步骤机制发挥作用。在这一历史视角中，我强调了通过一系列学科和方法在阐明真核转录机制方面取得的进展，以及新技术的发展如何推动了这一协调努力。
Transcription regulation is critical to organism development and homeostasis. Control of expression of the 20,000 genes in human cells requires many hundreds of proteins acting through sophisticated multistep mechanisms. In this Historical Perspective, I highlight the progress that has been made in elucidating eukaryotic transcriptional mechanisms through an array of disciplines and approaches, and how this concerted effort has been driven by the development of new technologies.