Six DWI questions you always wanted to know but were afraid to ask: clinical relevance for breast diffusion MRI
Six DWI questions you always wanted to know but were afraid to ask: clinical relevance for breast diffusion MRI
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DOI：
10.1007/s00330-019-06648-0
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发表时间：
2020-05-01
影响因子：
5.9
通讯作者：
Le Bihan, Denis
中科院分区：
文献类型：
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作者：
Iima, Mami;Partridge, Savannah C.;Le Bihan, Denis
扩散MRI（通常称为扩散加权成像或DWI）自20世纪80年代中期引入以来，特别是在研究神经系统疾病和肿瘤学方面，已经获得了巨大的增长。在标准化和质量控制似乎像以往一样重要，以支持广泛使用的时候，我们的目标是解决常见的基本问题，所产生的结果与DWI。我们以乳腺DWI为例重点讨论了六个问题，因为乳腺DWI越来越多地用于临床实践，但我们的大多数结论适用于DWI。我们特别表明，噪音可以在特定的DWI有害的方式。忽略这些噪音效应可能会导致错误的数据解释或结论，而作者和读者可能真的没有意识到这一点。在解决这六个问题的同时，我们给出了如何理解噪声效应的实际例子，在可能的情况下进行纠正，或利用我们的优势。忽略DWI中的噪声效应可能会导致错误的数据解释或结论，作者和读者可能真的没有意识到这一点。中心点体内表观扩散系数（ADC）随B值而降低，因此必须沿着ADC一起报告。中心点合成DWI以牺牲精确的扩散/微观结构表征为代价来提高对比度。
Diffusion MRI (often called diffusion-weighted imaging or DWI) has enjoyed a tremendous growth since its introduction in the mid-1980s, especially to investigate neurological disorders and in oncology. At a time when standardization and quality control appear as critical as ever to support widespread utilization, our aim was to address common fundamental questions that arise regarding results obtained with DWI. We focus on six questions taking breast DWI as an example, as breast DWI is increasingly used in clinical practice, but most of our conclusions would apply to DWI in general. We show especially that noise can act in a pernicious way specific to DWI. Ignoring such noise effects could lead to incorrect data interpretations or conclusions, of which authors and readers may be genuinely unaware. While addressing these six questions, we give practical examples of how noise effects can be understood, corrected when possible, or taken to our advantage. Key Points center dot Ignoring noise effects in DWI could lead to incorrect data interpretations or conclusions, of which authors and readers may be genuinely unaware. center dot In vivo apparent diffusion coefficient (ADC) decreases with b value, which must therefore be reported along with ADC. center dot Synthesized DWI boosts contrast at the expense of accurate diffusion/microstructure characterization.