Involvement of the Novel Two-Component NsrRS and LcrRS Systems in Distinct Resistance Pathways against Nisin A and Nukacin ISK-1 in Streptococcus mutans
Involvement of the Novel Two-Component NsrRS and LcrRS Systems in Distinct Resistance Pathways against Nisin A and Nukacin ISK-1 in Streptococcus mutans
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DOI：
10.1128/aem.00780-13
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发表时间：
2013-08-01
影响因子：
4.4
通讯作者：
Komatsuzawa, Hitoshi
中科院分区：
文献类型：
--
作者：
Kawada-Matsuo, Miki;Oogai, Yuichi;Komatsuzawa, Hitoshi
新的双组分系统NsrRS和LcrRS分别与变形链球菌对不同的羊毛硫抗生素乳链菌肽A和nukacin ISK-1的耐药性相关。NsrRS调节与乳链菌肽A结合相关的NsrX的表达，LcrRS调节ABC转运蛋白LctFEG的表达。
The novel two-component systems NsrRS and LcrRS are individually associated with resistance against the distinct lantibiotics nisin A and nukacin ISK-1 in Streptococcus mutans. NsrRS regulates the expression of NsrX, which is associated with nisin A binding, and LcrRS regulates the expression of the ABC transporter LctFEG.