NICOTINE ENHANCEMENT OF FAST EXCITATORY SYNAPTIC TRANSMISSION IN CNS BY PRESYNAPTIC RECEPTORS
NICOTINE ENHANCEMENT OF FAST EXCITATORY SYNAPTIC TRANSMISSION IN CNS BY PRESYNAPTIC RECEPTORS
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DOI：
10.1126/science.7569895
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发表时间：
1995-09-22
期刊：
影响因子：
56.9
通讯作者：
ROLE, LW
中科院分区：
文献类型：
--
作者：
MCGEHEE, DS;HEATH, MJS;ROLE, LW
尼古丁对行为和认知的影响表明尼古丁乙酰胆碱受体（nachr）参与中枢神经系统（CNS）功能。虽然nAChR亚基信使RNA （mRNA）和尼古丁结合位点在大脑中很常见，但很少有证据表明nAChR在中枢神经系统中介导突触。为了测试CNS nAChRs是否可能改变而不是介导传递，我们研究了这些受体对兴奋性突触传递的调节。纳摩尔浓度的尼古丁通过激活突触前nachr，增加突触前[Ca2+]，增强了谷氨酸能和胆碱能突触的传递(i)。药理学和亚基缺失实验表明，这些突触前nachr包括α 7亚基。这些发现表明，CNS nachr增强了快速兴奋传递，为尼古丁的复杂行为效应提供了可能的机制。
The behavioral and cognitive effects of nicotine suggest that nicotinic acetylcholine receptors (nAChRs) participate in central nervous system (CNS) function. Although nAChR subunit messenger RNA (mRNA) and nicotine binding sites are common in the brain, there is little evidence for synapses mediated by nAChRs in the CNS. To test whether CNS nAChRs might modify rather than mediate transmission, the regulation of excitatory synaptic transmission by these receptors was examined. Nanomolar concentrations of nicotine enhanced both glutamatergic and cholinergic synaptic transmission by activation of presynaptic nAChRs that increased presynaptic [Ca2+](i). Pharmacological and subunit deletion experiments reveal that these presynaptic nAChRs include the alpha 7 subunit. These findings reveal that CNS nAChRs enhance fast excitatory transmission, providing a likely mechanism for the complex behavioral effects of nicotine.