Revised Reference Curves for Bone Mineral Content and Areal Bone Mineral Density According to Age and Sex for Black and Non-Black Children: Results of the Bone Mineral Density in Childhood Study
Revised Reference Curves for Bone Mineral Content and Areal Bone Mineral Density According to Age and Sex for Black and Non-Black Children: Results of the Bone Mineral Density in Childhood Study
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DOI：
10.1210/jc.2011-1111
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发表时间：
2011-10-01
影响因子：
5.8
通讯作者：
Winer, Karen K.
中科院分区：
文献类型：
--
作者：
Zemel, Babette S.;Kalkwarf, Heidi J.;Winer, Karen K.
背景：生长过程中骨获取的缺陷可能会增加骨折风险。儿童时期的骨骼健康评估需要相对于年龄、性别和人口血统的适当参考值来识别骨骼缺陷。目的：本研究的目的是为儿童的骨矿物质含量 (BMC) 和面积骨矿物质密度 (aBMD) 提供修订和扩展的参考曲线。设计：儿童骨矿物质密度研究是一项多中心纵向研究，每年进行长达 7 年的评估。背景：该研究在美国的五个临床中心进行国家。参与者：2014 名 5-23 岁的健康儿童（992 名男性，22% 非洲裔美国人）参与了这项研究。干预：没有干预。主要结果指标：使用双能 X 射线骨密度测定法获得黑人和非黑人儿童全身、腰椎、髋部和前臂的 BMC 和 aBMD 参考百分位。还计算了身高状态的调整因子。 结果：相对于黑人和非黑人儿童的性别和年龄，构建了 5-20 岁的全身、全身减去头部、腰椎、全髋、股骨颈和前臂的 BMC 和 aBMD 的扩展参考曲线。曲线与之前发布的 7-17 岁儿童曲线相似。在所有测量点，黑人儿童的 BMC 和 aBMD 值均高于非黑人儿童。结论：我们在此提供了 2012 年儿童和青少年特征良好的双能 X 射线骨密度测定参考数据。这些参考曲线为迄今为止文献中儿童和青少年骨骼健康的评估和监测提供了最稳健的参考值。 (临床内分泌代谢杂志 96: 3160-3169, 2011)
Context: Deficits in bone acquisition during growth may increase fracture risk. Assessment of bone health during childhood requires appropriate reference values relative to age, sex, and population ancestry to identify bone deficits.Objective: The objective of this study was to provide revised and extended reference curves for bone mineral content (BMC) and areal bone mineral density (aBMD) in children.Design: The Bone Mineral Density in Childhood Study was a multicenter longitudinal study with annual assessments for up to 7 yr.Setting: The study was conducted at five clinical centers in the United States.Participants: Two thousand fourteen healthy children (992 males, 22% African-Americans) aged 5-23 yr participated in the study.Intervention: There were no interventions.Main Outcome Measures: Reference percentiles for BMC and aBMD of the total body, lumbar spine, hip, and forearm were obtained using dual-energy x-ray absorptiometry for Black and non-Black children. Adjustment factors for height status were also calculated.Results: Extended reference curves for BMC and aBMD of the total body, total body less head, lumbar spine, total hip, femoral neck, and forearm for ages 5-20 yr were constructed relative to sex and age for Black and non-Black children. Curves are similar to those previously published for 7-17 year olds. BMC and aBMD values were greater for Black vs. non-Black children at all measurement sites.Conclusions: We provide here dual-energy x-ray absorptiometry reference data on a well-characterized cohort of 2012 children and adolescents. These reference curves provide the most robust reference values for the assessment and monitoring of bone health in children and adolescents in the literature to date. (J Clin Endocrinol Metab 96: 3160-3169, 2011)