Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population.
Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population.
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DOI：
10.11604/pamj.2019.32.197.15129
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Satta, Dalila
中科院分区：
文献类型：
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作者：
Benenemissi, Ikram Hana;Sifi, Karima;Satta, Dalila
简介：就在最近，血管紧张素转换酶（ACE）插入/缺失（I/D）多态性被证实与人类癌症的发病机制和进化有关。因此，本研究关注于胶质瘤与ACE基因I/D多态性之间的最终关联的调查。方法：采用聚合酶链反应限制性片段长度多态性（PCR-RFLP）方法检测36例阿尔及利亚胶质瘤患者和195例健康对照者的ACE基因表达。结果：胶质瘤患者ACE I/D多态性的等位基因频率和基因型分布与对照组不同。ACE DD基因型在胶质瘤病例中的发生率（63.9%）高于对照组（33.8%），胶质瘤病例的易感性风险为3.64倍(与ID基因型相比，p
INTRODUCTION: Just recently, it has been established that the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is linked to the pathogenesis and to the evolution of human cancers. Therefore, the present study was concerned with the investigation of an eventual association between glioma and I/D polymorphism of the ACE gene.METHODS: The expression of ACE gene was detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis in 36 Algerian patients with glioma and 195 healthy controls.RESULTS: In glioma cases, allelic frequencies and genotypes distribution of the ACE I/D polymorphism were different from controls cases. ACE DD genotype were highly presented in glioma cases (63.9%) than controls (33.8%) and conferred 3.64-fold risk for predisposition in glioma cases (vs ID genotype, p