Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study
Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study
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DOI：
10.1097/hjh.0b013e32834abd06
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发表时间：
2011-10-01
影响因子：
4.9
通讯作者：
Tanigawa, Takeshi
中科院分区：
文献类型：
--
作者：
Tabara, Yasuharu;Saito, Isao;Tanigawa, Takeshi
目的中心主动脉血压（BP）被认为比肱袖血压与心血管疾病风险更密切相关。然而，胰岛素敏感性和抵抗对中枢血压的影响尚未完全了解。在这里，我们评估了胰岛素敏感性/抵抗和中央BP使用口服葡萄糖耐量test.Methods共1034名日本参与者参加了这项研究之间的关联。通过径向波形获得的肱动脉血压收缩晚期峰值（SBP 2）的绝对压力被认为是中心收缩压。结果SBP 2低于SBP 2，SBP 2低于SBP 2。（119 +/- 20，126 +/- 19 mmHg，P < 0.001），胰岛素敏感性降低的患者SBP和SBP 2之间的差异显著更大（第一、第二、第三和第四分位数分别为-8.2 +/-5.2、-7.2 +/- 5.3、-7.1 +/- 5.1和-6.5 +/- 4.9 mmHg; P = 0.002）和增加的胰岛素抵抗（-6.6 +/- 5.1，-6.6 +/- 4.8，-7.3 +/- 4.8，-8.5 +/- 5.6 mmHg，P < 0.001）。多元线性回归分析确定胰岛素敏感性降低（β = 0.067，P = 0.033）和胰岛素抵抗增加（beta =-0.081，P = 0.009），但不包括在内。结论胰岛素敏感性和胰岛素抵抗是影响SBP与SBP 2差值的重要因素，健康的一般人群，我们建议测量SBP 2在个人与受损的胰岛素作用，以准确地评估他们的风险发展为心血管疾病。J Hypertens 29：1948-1954（C）2011 Wolters Kluwer Health竖条Lippincott威廉姆斯& Wilkins.
Objective Central aortic blood pressure (BP) has been postulated to correlate more closely with cardiovascular disease risk than brachial cuff BP. However, the effect of insulin sensitivity and resistance on central BP is not fully understood. Here, we evaluated the associations between insulin sensitivity/resistance and central BP using the oral glucose tolerance test.Methods A total of 1034 Japanese participants were enrolled in this study. The absolute pressure of the late systolic peak (SBP2) of the brachial BP obtained by the radial waveform was considered to be the central systolic BP. Oral glucose tolerance test was performed by administering 75 g of glucose, and blood samples were obtained at 0, 60, 120 min after glucose loading.Results Mean SBP2 was found to be lower than mean brachial systolic BP (SBP) (119 +/- 20, 126 +/- 19 mmHg, P < 0.001), and differences between SBP and SBP2 were significantly larger in patients with reduced insulin sensitivity (-8.2 +/- 5.2, -7.2 +/- 5.3, -7.1 +/- 5.1, and -6.5 +/- 4.9 mmHg, in the first, second, third and fourth quartiles, respectively; P = 0.002) and increased insulin resistance (-6.6 +/- 5.1, -6.6 +/- 4.8, -7.3 +/- 4.8, -8.5 +/- 5.6 mmHg, P < 0.001). Multiple linear regression analysis identified reduced insulin sensitivity (beta = 0.067, P = 0.033) and increased insulin resistance (beta = -0.081, P = 0.009) as independent determinants of the difference between SBP and SBP2.Conclusion Given that both insulin sensitivity and insulin resistance were found to be significant determinants of the difference between SBP and SBP2 in a healthy general population, we suggest measuring the SBP2 in individuals with impaired insulin action in order to accurately assess their risk of developing cardiovascular disease. J Hypertens 29:1948-1954 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.