The Rhizosphere Microbiome: A Playground for Natural Product Chemists
The Rhizosphere Microbiome: A Playground for Natural Product Chemists
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DOI：
10.1055/s-0035-1560711
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发表时间：
2015-12-01
期刊：
影响因子：
2
通讯作者：
Wuest, William M.
中科院分区：
文献类型：
--
作者：
Keohane, Colleen E.;Steele, Andrew D.;Wuest, William M.
耐抗生素细菌的威胁是一场持续不断的战斗，一直困扰着科学家和医生。对过去方法的重新调查导致了对天然微生物组的质疑，目的是确定当地居民所采用的生存机制。根际就是这样一个例子；微生物的家园，能够产生各种必需化合物，如环脂肽、铁载体、群体感应分子和抗生素。这场正在进行的战斗的复杂性激发了我们对一种物种特异性天然产物的合成努力，promysalin，从斯里兰卡的一株水稻的根际分离出来。最近，本课题组完成了该化合物的全合成、绝对结构赋值，并鉴定出独特的生物活性。这些努力使我们对其在根际内的作用机制和作用有了深入的了解。
The threat of antibiotic-resistant bacteria is an ongoing battle that continues to confound scientists and doctors alike. Reinvestigation of past methods has led to the interrogation of natural microbiomes with the goal of identifying the survival mechanisms employed by its local inhabitants. One such example is that of the rhizosphere; home to many microorganisms capable of producing a variety of essential compounds, such as cyclic lipopeptides, siderophores, quorum sensing molecules, and antibiotics. The intricacies of this ongoing battle inspired our synthetic efforts toward a species-specific natural product, promysalin, isolated from the rhizosphere of a rice plant in Sri Lanka. Recently, our group completed the total synthesis, absolute structural assignment, and identified unique bioactivity. These efforts have informed our insights toward its mechanism of action and role within the rhizosphere.