Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2.
Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2.
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DOI：
10.1084/jem.123.3.547
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发表时间：
1966-03-01
影响因子：
15.3
通讯作者：
Dray, S
中科院分区：
文献类型：
--
作者：
Cebra, J J;Colberg, J E;Dray, S
超免疫兔脾和淋巴结中的类淋巴细胞被发现相对于它们所含的免疫球蛋白重链的类别而分化。含有各种重链的细胞的相对比例如下：α链（5 - 8%）、µ链（14 - 21%）和γ链（71 - 81%）。在重链上发现的同种异型标记Aa 1和Aa 2也分别位于Aa 1/Aa 2杂合子兔的细胞中。脾脏和淋巴结中含有Aa 1标记物的细胞与含有Aa 2标记物的细胞的比例因家兔个体而异;范围为53 - 88% Aa 1与12 - 47% Aa 2。
Lymphoid cells present in spleen and lymph nodes of hyperimmune rabbits were found to be differentiated with respect to the class of immunoglobulin heavy chain which they contained. The relative proportions of cells containing the various heavy chains were as follows: α-chain (5 to 8%), µ-chain (14 to 21%), and γ-chain (71 to 81%). The allotypic markers Aa1 and Aa2, found on heavy chains, were also found to be separately localized in cells of Aa 1/Aa 2 heterozygous rabbits. The ratio of cells in spleen and lymph nodes containing the Aa1 marker to those containing the Aa2 marker varied with individual rabbits; the range was 53 to 88% Aa1 versus 12 to 47% Aa2.