Transmission of equine influenza virus to dogs
Transmission of equine influenza virus to dogs
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DOI：
10.1126/science.1117950
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发表时间：
2005-10-21
期刊：
影响因子：
56.9
通讯作者：
Donis, RO
中科院分区：
文献类型：
--
作者：
Crawford, PC;Dubovi, EJ;Donis, RO
对赛狗严重呼吸道疾病爆发中分离出的三种流感病毒的分子和抗原分析表明，它们与 H3N8 马流感病毒密切相关。系统发育分析表明，犬流感病毒基因组形成单系群，与单一种间病毒转移一致。血凝素的分子变化表明新宿主的适应性进化。抗体滴度上升与疾病的时间关联以及实验性接种研究支持了该病毒在呼吸道疾病中的病因作用。感染的地理范围扩大及其持续数年表明犬流感病毒在灰狗中有效传播。宠物狗感染的证据表明，这种感染也可能在该人群中流行。
Molecular and antigenic analyses of three influenza viruses isolated from outbreaks of severe respiratory disease in racing greyhounds revealed that they are closely related to H3N8 equine influenza virus. Phylogenetic analysis indicated that the canine influenza virus genomes form a monophyletic group, consistent with a single interspecies virus transfer. Molecular changes in the hemagglutinin suggested adaptive evolution in the new host. The etiologic role of this virus in respiratory disease was supported by the temporal association of rising antibody titers with disease and by experimental inoculation studies. The geographic expansion of the infection and its persistence for several years indicate efficient transmission of canine influenza virus among greyhounds. Evidence of infection in pet dogs suggests that this infection may also become enzootic in this population.