Peroxidase activity enhancement of horse cytochrome c by dimerization.
Peroxidase activity enhancement of horse cytochrome c by dimerization.
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DOI：
10.1039/c1ob05552f
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发表时间：
2011-06
影响因子：
3.2
通讯作者：
Zhonghua Wang;T. Matsuo;S. Nagao;S. Hirota
中科院分区：
文献类型：
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作者：
Zhonghua Wang;T. Matsuo;S. Nagao;S. Hirota
马细胞色素c的二聚化增强了其过氧化物酶活性，在与过氧化氢和间氯过苯甲酸的反应中分别检测到化合物III(氧基)和化合物I(氧基铁基卟啉π-阳离子自由基)。这些结果表明，寡聚体细胞色素c可以通过提高过氧化物酶活性来促进细胞凋亡。
The peroxidase activity of horse cytochrome c was enhanced by its dimerization, where its Compound III (oxy-form) and Compound I (oxoferryl porphyrin π-cation radical) species were detected in the reactions with hydrogen peroxide and meta-chloroperbenzoic acid, respectively. These results show that oligomeric cytochrome c can contribute as a proapoptotic conformer by the increased peroxidase activity.