Relationship of serum uric acid to cancer occurrence in a prospective male cohort.
Relationship of serum uric acid to cancer occurrence in a prospective male cohort.
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发表时间：
1994-04
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通讯作者：
L. Kolonel;C. Yoshizawa;A. Nomura;G. Stemmermann
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作者：
L. Kolonel;C. Yoshizawa;A. Nomura;G. Stemmermann
尿酸是一种有效的抗氧化剂，因此可以预防癌症。为了验证这一假设，我们在夏威夷的一组日本男性中研究了血清尿酸与随后癌症发病率的关系。研究人群包括1965-1968年确定的7889名男性，并在1991年11月进行了积极的医院监测。使用考克斯比例风险回归分析血清尿酸水平的癌症风险，并根据年龄以及（如有指示）吸烟、饮酒和体重指数进行调整。未观察到总癌症（1544例）或胃癌（214例）、结肠癌（272例）、直肠癌（105例）、肺癌（223例）、膀胱癌（89例）或造血系统癌（77例）的显著相关性。对于前列腺癌（293例），发现了正相关（血清尿酸最高与最低四分位数的相对风险= 1.5; 95%置信区间1.1-2.1;趋势p = 0.04）。当考虑到从检查到诊断的时间间隔时，这种关联在前10年诊断的病例中最强，15年后减弱，20年后完全消失。这项研究的结果不支持尿酸预防癌症发生的假设。
Uric acid is a potent antioxidant and thus might protect against cancer. To test this hypothesis, we examined the relationship of serum uric acid to subsequent cancer incidence in a cohort of Japanese men in Hawaii. The study population consisted of 7889 men identified in the years 1965-1968 and followed by active hospital surveillance through November 1991. Cancer risk by serum uric acid level was analyzed using Cox proportional hazards regression with adjustment for age and, where indicated, smoking, alcohol use, and body mass index. No significant associations were seen for total cancer (1544 cases), or for cancers of the stomach (214), colon (272), rectum (105), lung (223), bladder (89), or hematopoietic system (77). For prostate cancer (293 cases), a positive association was found (relative risk for highest versus lowest quartile of serum uric acid = 1.5; 95% confidence interval 1.1-2.1; p for trend = 0.04). When the interval from examination to diagnosis was considered, this association was strongest for cases diagnosed in the first 10 years, was attenuated after 15 years, and disappeared completely after 20 years. The findings from this study do not support the hypothesis that uric acid protects against cancer occurrence.