Changes in human plasma atrial natriuretic polypeptide concentration in normal subjects during passive leg raising and whole-body tilting.
Changes in human plasma atrial natriuretic polypeptide concentration in normal subjects during passive leg raising and whole-body tilting.
复制标题
正常受试者被动抬腿和全身倾斜时人血浆心钠素浓度的变化。
DOI：
10.1042/cs0710147
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发表时间：
1986
期刊：
影响因子：
6
通讯作者：
H. Matsuo
中科院分区：
文献类型：
--
作者：
Toshio Ogihara;Junko Shima;H. Hara;Yuichi Kumahara;K. Kangawa;H. Matsuo
通过测量正常志愿者被动抬腿至 60 度和抬头全身倾斜 60 度期间的血浆 hANP 水平，研究中心静脉压对人心房钠尿肽 (hANP) 释放的影响。 10 名受试者在躺卧至少 1 小时后，双腿被动抬高 60 度持续 20 分钟。当腿抬起时，血浆 hANP 水平从 101 +/- 10 pg/ml（平均值 +/- SE）的基础水平显着增加到 10 分钟后的峰值 165 +/- 15 pg/ml，并在腿放下后 10 分钟恢复到基础水平。抬腿不会影响血压和脉搏。在 9 名正常受试者中检查了从仰卧位开始全身倾斜 60 度持续 20 分钟的效果。其中 5 名受试者的血浆 hANP 在 5 分钟内短暂下降，其余 4 名受试者则在 10 分钟或更晚时出现短暂下降。当身体倾斜时，他们的血压没有变化，但脉搏明显增加。这些结果表明，hANP 的分泌在生理上受到中心静脉压变化的调节。
The effect of central venous pressure on release of human atrial natriuretic polypeptide (hANP) was studied by measuring the plasma hANP levels during passive leg raising to 60 degrees and head up whole-body tilt at 60 degrees in normal volunteers. In ten subjects, after at least 1 h recumbency, both legs were raised passively 60 degrees for 20 min. While the legs were raised the plasma hANP level increased significantly from a basal level of 101 +/- 10 pg/ml (mean +/- SE) to a peak of 165 +/- 15 pg/ml after 10 min, and returned to the basal level 10 min after the legs were lowered. The blood pressure and pulse rate were not affected by raising the legs. The effect of head up whole-body tilt of 60 degrees from the supine position, for 20 min, was examined in nine normal subjects. Their plasma hANP decreased transiently at 5 min in five of them and at 10 min or later in the remaining four subjects. Their blood pressure did not change but their pulse rate increased significantly while their body was being tilted. These results suggest that secretion of hANP is regulated physiologically by changes in the central venous pressure.