The role of FSH in body composition in hematopoietic cell transplant recipients.
The role of FSH in body composition in hematopoietic cell transplant recipients.
复制标题
FSH 在造血细胞移植受者身体成分中的作用。
DOI：
10.1111/petr.14130
复制
发表时间：
2022
影响因子：
1.3
通讯作者：
Baker,Scott
中科院分区：
文献类型：
--
作者：
Roelofs,EricaJ;Dengel,DonaldR;Wang,Qi;Hodges,JamesS;Steinberger,Julia;Baker,Scott
接受造血细胞移植（HCT）的儿童癌症幸存者发生促卵泡激素（FSH）异常的风险增加，这可能对骨骼健康和身体组成产生重大负面影响。本研究的目的是检查卵泡刺激素和身体成分在HCT受体，non-HCT受体和healthcontrols.MethodsThe研究包括HCT受体（n= 24），non-HCT受体（n= 309），和健康的同胞对照组（n= 211），年龄均为9-18岁。采集空腹血液样本以测量FSH。所有受试者均接受双X射线吸收扫描，以评估总脂肪和局部脂肪百分比、瘦体重（LM）、脂肪量（FM）、骨矿物质含量（BMC）、骨矿物质密度（BMD）和内脏脂肪组织（VAT）质量。与非HCT接受者和健康对照相比，HCT接受者具有显著较低的总体重、总LM、手臂和腿部LM、BMC和BMD（p<0.05）。与健康对照相比，非HCT接受者的总FM、躯干FM、android FM、gynoid FM、手臂FM和腿部FM显著更高。此外，健康对照组有显着较低的增值税质量相比，non-HCT recipients.ConclusionsThis研究的结果表明，HCT收件人有显着降低BMD，更糟糕的身体成分，和异常FSH水平相比，non-HCT收件人和健康对照组。
BackgroundChildhood cancer survivors who received a hematopoietic cell transplantation (HCT) are at increased risk for follicle‐stimulating hormone (FSH) abnormalities, which may have a significant negative impact on bone health and body composition. This study's purpose was to examine FSH and body composition in HCT recipients, non‐HCT recipients and healthy controls.MethodsThe study included HCT recipients (n= 24), non‐HCT recipients (n= 309), and a control group of healthy siblings (n= 211) all aged 9–18 years. A fasting blood sample was collected to measure FSH. All participants underwent a dual X‐ray absorptiometry scan to assess total and regional percent fat, lean mass (LM), fat mass (FM), bone mineral content (BMC), bone mineral density (BMD), and visceral adipose tissue (VAT) mass.ResultsFSH was significantly higher in HCT recipients compared to non‐HCT recipients and healthy controls. HCT recipients had significantly lower total body weight, total LM, arm and leg LM, BMC and BMD compared to non‐HCT recipients and healthy controls (p< .05). Non‐HCT recipients had significantly higher total, trunk, android, gynoid, arm and leg FM compared to healthy controls. Also, healthy controls had significantly lower VAT mass compared to non‐HCT recipients.ConclusionsThis study's results show that HCT recipients have significant reductions in BMD, worse body composition, and abnormal FSH levels compared to non‐HCT recipients and healthy controls.