Novel synthetic route of aryl-aminopyrazine
Novel synthetic route of aryl-aminopyrazine
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DOI：
10.1016/j.tet.2003.11.052
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发表时间：
2004-01-19
期刊：
影响因子：
2.1
通讯作者：
Isobe, M
中科院分区：
文献类型：
--
作者：
Kuse, M;Kondo, N;Isobe, M
报道了一种新的芳氨基吡嗪的合成路线。从Boc-甘氨酸和氨基腈开始，经几步制备氨基吡嗪环。在氨基吡嗪酮的三氟甲烷磺酰化之后，使所得的三氟甲磺酸酯与芳基硼酸进行Suzuki-Miyaura偶联反应，得到腔肠胺。(C)2003爱思唯尔有限公司。保留所有权利。
We report a novel synthetic route of aryl-aminopyrazine through a new cyclization reaction by using a hydroxylamine. Starting from Boc-glycine and aminonitrile, the aminopyrazine ring was prepared in several steps. After trifluoromethane sulfonylation of the aminopyrazinone, the resultant triflate was subjected to Suzuki-Miyaura coupling reaction with aryl boronic acid to afford coelenteramine. (C) 2003 Elsevier Ltd. All rights reserved.