Impact of Disturbed Rest-activity Rhythms on Activities of Daily Living in Moderate and Severe Dementia Patients
Impact of Disturbed Rest-activity Rhythms on Activities of Daily Living in Moderate and Severe Dementia Patients
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DOI：
10.1097/wad.0000000000000423
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发表时间：
2021-04-01
影响因子：
2.1
通讯作者：
Nishikawa, Takashi
中科院分区：
文献类型：
--
作者：
Ishimaru, Daiki;Tanaka, Hiroyuki;Nishikawa, Takashi
目的：痴呆症患者在整个疾病过程中表现出休息-活动节律紊乱和睡眠持续时间延长的问题。关于这些问题对中度和重度痴呆症患者临床问题的影响知之甚少。这项横断面研究的目的是研究的关联性紊乱的休息-活动节律和延长的睡眠时间与日常生活活动（ADL）。方法：睡眠参数进行了测量，使用体动仪。认知功能采用简易精神状态检查和重度痴呆认知测试进行评估，日常生活活动量表用于评估日常生活活动，痴呆的行为和心理症状采用神经精神量表-护理之家量表进行评估。采用多元线性回归分析静息-活动节律、睡眠持续时间和其他临床变量之间的关系。临床变量进行了比较2组之间的发病时间的休息peak.Patients：64名参与者与中度和重度dementia进行了assessed.Results：在相关性分析中，不稳定的日常休息活动节律与较低的ADL。在多元线性回归分析中，低的日内变异性和长的白天睡眠时间与低ADL相关。结论：中重度痴呆患者静息-活动节律和睡眠时间异常可能影响ADL。
Purpose:People with dementia exhibit disturbed rest-activity rhythms and extended sleep duration issues throughout their disease. Little is known about the effects of these issues on clinical problems for those with moderate and severe dementia. This cross-sectional study aimed to examine the associations of disturbed rest-activity rhythms and extended sleep duration with activities of daily living (ADL).Methods:Sleep parameters were measured using an actigraphy device. Cognitive function was assessed using the Mini-Mental State Examination and Cognitive Test for Severe Dementia, the Hyogo Activities of Daily Living Scale was used to assess ADL, and behavioral and psychological symptoms of dementia were assessed using the Neuropsychiatric Inventory-Nursing Home scale. Associations among rest-activity rhythms, sleep duration, and other clinical variables were analyzed with multiple linear regression. Clinical variables were compared between 2 groups categorized by onset timing of rest peak.Patients:Sixty-four participants with moderate and severe dementia were assessed.Results:In the correlation analysis, unstable daily rest-activity rhythm was associated with lower ADL. In the multiple linear regression analysis, low intradaily variability, and long daytime sleep duration were associated with low ADL. Aberrant rest peak timing showed lower ADL compared with nonaberrant timing.Conclusions:Abnormal rest-activity rhythm and sleep duration in persons with moderate and severe dementia may affect ADL.