Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis.
Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis.
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DOI：
10.1186/s12915-021-01032-1
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发表时间：
2021-05-17
期刊：
影响因子：
5.4
通讯作者：
Pires-daSilva A
中科院分区：
文献类型：
--
作者：
Robles P;Turner A;Zuco G;Adams S;Paganopolou P;Winton M;Hill B;Kache V;Bateson C;Pires-daSilva A
亲代经历的环境刺激影响后代的表型（Demoinet et al.，Proc Natl Acad Sci U S A 114：E2689-E2698，2017; Burton等人，Nat Cell Biol 19：252-257，2017; Agrawal等人，Nature 401：60-63，1999）。这些刺激对亲代的影响可能会通过种系传递，但这种非孟德尔遗传类型的基础机制，它们的保守程度，它们如何导致适应性与非适应性，以及代际与跨代遗传，都知之甚少。在这里，我们表明，调制的营养感应途径在父母一代的线虫Auanema freiburgensis调节其后代的表型可塑性。响应于指示应激的con-specific信息素，AMP活化的蛋白激酶（AMPK）、雷帕霉素复合物1的机制靶点（mTORC 1）和胰岛素信号传导在一代人中调节应激抗性和性别决定，并且这些作用可以通过途径调节剂来模拟。这些途径的效应子与染色质密切相关，它们的调节影响生殖细胞中染色质乙酰化状态。这些结果表明，高度保守的代谢传感器调节表型可塑性，通过调节其效应子的亚细胞定位，导致染色质乙酰化和表观遗传状态的种系的变化。在线版本包含补充材料，可通过10.1186/s12915-021-01032-1获得。
Environmental stimuli experienced by the parental generation influence the phenotype of subsequent generations (Demoinet et al., Proc Natl Acad Sci U S A 114:E2689-E2698, 2017; Burton et al., Nat Cell Biol 19:252–257, 2017; Agrawal et al., Nature 401:60-63, 1999). The effects of these stimuli on the parental generation may be passed through the germline, but the mechanisms at the basis of this non-Mendelian type of inheritance, their level of conservation, how they lead to adaptive vs non-adaptive, and intergenerational vs transgenerational inheritance are poorly understood. Here we show that modulation of nutrient-sensing pathways in the parental generation of the nematode Auanema freiburgensis regulates phenotypic plasticity of its offspring. In response to con-specific pheromones indicative of stress, AMP-activated protein kinase (AMPK), mechanistic target of rapamycin complex 1 (mTORC1), and insulin signaling regulate stress resistance and sex determination across one generation, and these effects can be mimicked by pathway modulators. The effectors of these pathways are closely associated with the chromatin, and their regulation affects the chromatin acetylation status in the germline. These results suggest that highly conserved metabolic sensors regulate phenotypic plasticity through regulation of subcellular localization of their effectors, leading to changes in chromatin acetylation and epigenetic status of the germline. The online version contains supplementary material available at 10.1186/s12915-021-01032-1.
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DOI：
10.1073/pnas.1616171114
发表时间：
2017-03-28
影响因子：
11.1
作者：
Demoinet, Emilie;Li, Shaolin;Roy, Richard
通讯作者：
Roy, Richard
影响因子：
4.6
作者：
Adams, Sally;Pathak, Prachi;Pires-daSilva, Andre
通讯作者：
Pires-daSilva, Andre
影响因子：
11.4
作者：
Boudeau, J;Baas, AF;Alessi, DR
通讯作者：
Alessi, DR
影响因子：
4.6
作者：
Chaudhuri J;Bose N;Tandonnet S;Adams S;Zuco G;Kache V;Parihar M;von Reuss SH;Schroeder FC;Pires-daSilva A
通讯作者：
Pires-daSilva A
影响因子：
2.7
作者：
CASSADA, RC;RUSSELL, RL
通讯作者：
RUSSELL, RL