Ornithine decarboxylase: an unreliable marker for the identification of population groups at risk for colonic neoplasia.
Ornithine decarboxylase: an unreliable marker for the identification of population groups at risk for colonic neoplasia.
复制标题
鸟氨酸脱羧酶：用于识别结肠肿瘤风险人群的不可靠标记。
DOI：
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发表时间：
1990
影响因子：
9.8
通讯作者：
W. Jacobsohn
中科院分区：
文献类型：
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作者：
D. Braverman;H. Stankiewicz;R. Goldstein;J. Patz;G. Morali;W. Jacobsohn
鸟氨酸脱羧酶（ODC）是多胺生物合成途径中的第一酶和限速酶。多胺已被研究作为肿瘤疾病的潜在标记物，包括结肠癌。以往的研究已经指出了该酶作为结肠肿瘤的生化标志物的可能价值，我们研究了100例进行诊断性全结肠镜检查的患者。正常对照40例，每组20例：1)诊断为结肠肿瘤患者家属，2)腺瘤患者，3)结肠腺癌患者。从正常的乙状结肠粘膜取6个钳活检分析ODC。在四组研究中没有发现差异。因此，我们得出结论，ODC在临床上作为识别结肠肿瘤危险人群的生化标志物是不可靠的。
Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines have been studied as potential markers of neoplastic diseases, including colonic cancer. Previous studies have pointed out the possible value of this enzyme as a biochemical marker of colonic neoplasia, we studied 100 patients undergoing diagnostic total colonoscopy. There were 40 normal controls and 20 patients in each of the following groups: 1) family members of patients diagnosed as having colonic tumors, 2) patients with adenomas, and 3) patients with colonic adenocarcinoma. Six forceps biopsies were obtained from the normal-appearing sigmoid mucosa for the analysis of ODC. No difference was found among the four groups studied. We therefore conclude that ODC is unreliable for clinical use as a biochemical marker for the identification of population groups at risk for colonic neoplasia.