The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn's Disease: A Review.
The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn's Disease: A Review.
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DOI：
10.3390/nu9050447
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发表时间：
2017-05-01
期刊：
影响因子：
5.9
通讯作者：
Van Limbergen J
中科院分区：
文献类型：
--
作者：
MacLellan A;Moore-Connors J;Grant S;Cahill L;Langille MGI;Van Limbergen J
克罗恩病（CD）是炎症性肠道疾病（IBD）的一种形式，被认为是由遗传学、肠道微生物组和环境因素（例如饮食）的复杂相互作用引起的。有明确的证据表明，饮食干预在CD治疗中是成功的-完全肠内营养（EEN）能够在高达80%的CD患者中诱导缓解。虽然EEN的作用机制尚不清楚，但已知EEN会引起肠道微生物组的深刻变化。了解EEN如何改变肠道微生物组以诱导缓解可以深入了解CD的发病机制，并有助于开发针对微生物组的干预措施，以指导正在进行的饮食治疗以维持缓解。本综述包括目前关于CD患者EEN治疗相关肠道微生物组组成和功能变化的文献。
Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD—exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients.